Hepatoprotective effect of water bamboo shoot (Zizania latifolia) extracts against acute alcoholic liver injury in a mice model and screening of bioactive phytochemicals
文献类型： 外文期刊
第一作者： Gao, Yuan
作者： Gao, Yuan;Zong, Zihao;Xia, Wei;Fang, Xiangjun;Liu, Ruiling;Wu, Weijie;Mu, Honglei;Han, Yanchao;Xiao, Shangyue;Gao, Haiyan;Chen, Hangjun;Xiao, Shangyue;Gao, Yuan
作者机构：
关键词： alcoholic liver injury; bioactive phytochemicals; NF-kappa B pathway; proinflammatory cytokines; water bamboo shoot
期刊名称：FOOD FRONTIERS （ 影响因子：9.9； 五年影响因子：10.0 ）
ISSN：
年卷期： 2023 年
页码：
收录情况： SCI
摘要： In this study, the hepatoprotective effect of alkali extract (NE) of water bamboo shoot (WBS) against acute alcoholic liver injury (ALI) in mice was evaluated, and its underlying mechanisms were explored. Animal experiment demonstrated that NE exhibited hepatoprotective effect on alcoholic intake-induced ALI via significantly enhancing the hepatic activities of alcohol dehydrogenase (ADH), acetaldehyde dehydrogenase (ALDH), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and catalase (CAT), whereas significantly attenuated hepatic levels of malondialdehyde (MDA), interleukin-1 beta (IL-1 beta), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha). The potential molecular mechanism and bioactive compounds of NE against ALI were explored by bioinformatics analysis and isosinensetin was found to be themajor bioactive compounds in NE against ALI. The western blot analysis showed that NE inhibited phosphorylation of p65 and I.Ba to suppress the NF-.B pathway. Overall our result indicated thatWBS possesses potential hepatoprotective effects against ALI.
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