Underlying effect of TDG supersaturation on Hypophthalmichthys molitrix in the Dadu River

文献类型： 外文期刊

第一作者： Zhang, Yuanyi

作者： Zhang, Yuanyi;Zhang, Qiyu;Wang, Fei;Shi, Haoran;Yang, Yao;Liu, Xiaoqing;Cai, Lu;Luo, Xiaohan;Chen, Yeyu

作者机构：

关键词： Total dissolved gas (TDG) supersaturation; Hypophthalmichthys molitrix; Energy metabolism; Immunity; Amino acid metabolism

期刊名称：JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING （ 影响因子：7.2； 五年影响因子：7.6 ）

ISSN： 2213-2929

年卷期： 2025 年 13 卷 5 期

页码：

收录情况： SCI

摘要： The total dissolved gas (TDG) supersaturation caused by flood discharge from dams seriously threatens the survival of aquatic organisms, especially fish. However, few field studies have assessed how TDG supersaturation affects fish in natural rivers during flood events. Additionally, no field studies have reported the physiological changes in fish and the molecular mechanisms underlying the effects of TDG on fish when floods are discharged from dams. In this study, Hypophthalmichthys molitrix was exposed to TDG-supersaturated water for 48 h in the Dadu River during flood discharge. The physiological effects of TDG supersaturation stress on H. molitrix and the potential molecular mechanism involved were investigated on the basis of histopathological, biochemical, transcriptomic and metabolomic data. Pathohistological findings demonstrated that the gills of H. molitrix were severely damaged after TDG exposure. The biochemical results revealed significant decreases in catalase and aspartate aminotransferase levels, whereas alanine aminotransferase levels increased significantly. For gill tissue, transcriptomic analysis revealed 6028 differentially expressed genes, including 3235 (53.6 %) upregulated genes and 2793 (46.4 %) downregulated genes. Metabolomics revealed 115 differentially enriched metabolites. Furthermore, the results revealed that TDG stress induced significant upregulations of many immune-related genes. TDG supersaturation stress caused significant changes in ATP-related genes and lipid metabolism. TDG supersaturation stress could affect ABC transporter and glycerophospholipid metabolism. This is the first field investigation revealing the potential molecular mechanisms underlying the effects of TDG on fish in natural rivers. Our results can help to elucidate the ecological impacts of TDG supersaturation and compensate for the deficiencies of previous studies.

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