Evaluation of radicals scavenging, immunity-modulatory and antitumor activities of longan polysaccharides with ultrasonic extraction on in S180 tumor mice models

文献类型： 外文期刊

第一作者： Zhong, Kui

作者： Zhong, Kui;Wang, Qiang;He, Yin;He, Xuanhui

作者机构：

关键词： Antitumor effect;Immunity-modulatory;Longan polysaccharides;Radicals scavenging;S180 tumor

期刊名称：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES （ 影响因子：6.953； 五年影响因子：6.737 ）

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收录情况： SCI

摘要： Longan (Dimocarpus longan Lour.) is used as a traditional edible and medicinal material in China. In this paper, the effects of polysaccharides from longan pulp with ultrasonic extraction (UELP) on the radicals scavenging, immunity-modulatory and antitumor activities in S180 tumor mice models were investigated. UELP showed excellent scavenging activity on the hydroxyl radicals and a,a-diphenyl-1-picrylhydrazyl (DPPH) radicals, and obtained the almost complete scavenging effect. UELP with medium-dose (200. mg/kg) and low-dose (100. mg/kg) had potent immune-modulatory effects in S180 tumor mice model and exhibited significant effect on delayed-type hypersensitivity (DTH) response, macrophage phagocytosis and ConA-stimulated splenocyte proliferation as compared with model control treatment (p<0.01). The results still showed that UELP had great antitumor effects, and maximum inhibition rate was obtained at medium-dose and low-dose (200 and 100. mg/kg).

分类号： Q71

  • 相关文献

[1]Optimization of ultrasonic extraction of polysaccharides from dried longan pulp using response surface methodology. Zhong, Kui,Wang, Qiang,Zhong, Kui.

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