Exosomes Derived From Dendritic Cells Infected With Toxoplasma gondii Show Antitumoral Activity in a Mouse Model of Colorectal Cancer
文献类型： 外文期刊
第一作者： Lu, Jinmiao
作者： Lu, Jinmiao;Zhu, Shilan;Chen, Xiaoyu;Li, Guoqing;Lu, Jinmiao;Zhu, Shilan;Chen, Xiaoyu;Gong, Haiyan;Mi, Rongsheng;Huang, Yan;Chen, Zhaoguo;Wei, Nana
作者机构：
关键词： Toxoplasma gondii; exosomes; myeloid derived suppressor cells (MDSCs); dendritic cells (DCs); colorectal cancer (CRC); immunosuppression
期刊名称：FRONTIERS IN ONCOLOGY （ 影响因子：5.738； 五年影响因子：6.122 ）
ISSN： 2234-943X
年卷期： 2022 年 12 卷
页码：
收录情况： SCI
摘要： Pathogen-based cancer therapies have been widely studied. Parasites, such as Toxoplasma gondii have elicited great interest in cancer therapy. Considering safety in clinical applications, we tried to develop an exosome-based immunomodulator instead of a live parasite for tumor treatment. The exosomes, called DC-Me49-exo were isolated from culture supernatants of dendritic cells (DCs) infected with the Me49 strain of T. gondii and identified. We assessed the antitumoral effect of these exosomes in a mouse model of colorectal cancer (CRC). Results showed that the tumor growth was significantly inhibited after treatment with DC-Me49-exo. Proportion of polymorphonuclear granulocytic bone marrow-derived suppressor cells (G-MDSCs, CD11b(+)Ly6G(+)) and monocytic myeloid-derived suppressor cells (M-MDSCs, CD11b(+)Ly6C(+)) were decreased in the DC-Me49-exo group compared with the control groups in vitro and in vivo. The proportion of DCs (CD45(+)CD11c(+)) increased significantly in the DC-Me49-exo group. Levels of interleukin-6 (IL-6) and granulocyte-macrophage colony-stimulating factor (GM-CSF) significantly decreased after treatment with DC-Me49-exo. Furthermore, we found that DC-Me49-exo regulated the lever of MDSC mainly by inhibiting the signal transducer and activator of transcription (STAT3) signaling pathway. These results indicated that exosomes derived from DCs infected with T. gondii could be used as part of a novel cancer therapeutic strategy by reducing the proportion of MDSCs.
分类号：
- 相关文献
作者其他论文 更多>>
-
Genome-wide methylation and transcriptome analysis in koi carp (Cyprinus carpio var. koi): Uncovering novel molecular mechanisms in skin color differentiation and pigmentation
作者：Shi, Xiulan;Chen, Xiaoyu;Dong, Zaijie;Zhu, Wenbin;Fu, Jianjun;Wang, Lanmei;Luo, Mingkun;Dong, Zaijie;Guo, Jun;Lin, Kai
关键词：Koi carp; Skin color; DNA methylation; RNA-sequencing
-
Difference Analysis on Virulence Genes, Biofilms and Antimicrobial Susceptibility of Escherichia coli from Clinical and Subclinical Bovine Mastitis
作者：Zuo, Jiakun;Fu, Shaodong;Pan, Zihao;Yu, Yong;Miao, Jinfeng;Zuo, Jiakun;Lv, Zhaoyang;Lian, Liyan;Zhang, Haiyang;Jiang, Wei;Chen, Zhaoguo;Han, Xiangan;Lv, Zhaoyang;Wu, Zihao;Wu, Jing;Chen, Wei;Yin, Huifang;Yi, Yunpeng
关键词：Escherichia coli; bovine mastitis; MLST; biofilm; virulence gene; antimicrobial resistance
-
Role of fdhD in the pathogenicity and its regulatory characteristics in avian pathogenic Escherichia coli
作者：Nawaz, Saqib;Wang, Zhihao;Chen, Zhaoguo;Jiang, Wei;Han, Xiangan;Yin, Huifang;Bao, Yinli;Huang, Cuiqin
关键词：Avian pathogenic E. coli; FdhD; Virulence; Quorum sensing regulator LsrR
-
Effects of Orally Delivered Double-Stranded RNA of Trehalose-6-Phosphate Synthase on the Population of Frankliniella occidentalis
作者：Lin, Tao;Chen, Xiaoyu;Chen, Ying;Liang, Xueyi;Yang, Guang;Lin, Tao;Chen, Ting;Wei, Hui;Lin, Tao;Chen, Xiaoyu;Chen, Ying;Liang, Xueyi;Yang, Guang;Lin, Tao;Chen, Xiaoyu;Chen, Ying;Liang, Xueyi;Yang, Guang
关键词：feeding; trehalose-6-phosphate synthase; life table; population suppression; bacterially expressed dsRNA; western flower thrip
-
Inactivation effects of slightly acidic electrolyzed water on Cryptosporidium baileyi and Eimeria tenella
作者：Huang, Yan;Li, Qiuxiang;Chen, Zhaoguo;Huang, Shixin;Gu, Xin;Song, Hongyou
关键词：Slightly acidic electrolyzed water; Parasitic disease of chick; Cryptosporidium baileyi; Eimeria tenella; Inhibitory effect
-
Molecular characterization of Klebsiella pneumoniae in clinical bovine mastitis in 14 provinces in China
作者：Wusiman, Maierhaba;Yin, Huifang;Huang, Cuiqin;Han, Xiangan;Wusiman, Maierhaba;Zuo, Jiakun;Lv, Zhaoyang;Wang, Mengdi;Nie, Lianhua;Wu, Zihao;Jiang, Wei;Chen, Zhaoguo;Han, Xiangan;Wusiman, Maierhaba;Lv, Zhaoyang;Zhang, Xiuping;Wu, Jing;Wu, Zihao;Chen, Wei;Zuo, Jiakun;Yu, Yong;Pan, Zihao;Zhang, Wei;Miao, Jinfeng
关键词：Bovine mastitis;
Klebsiella pneumoniae ; Antibiotic resistance; Biofilm; Acylated homoserine lactone -
Toxoplasma gondii Type I TR and ROP16 Synergistically Downregulate IL-12 to Inhibit Host Reactive Oxygen Species Production
作者：Geng, Xiaoling;Li, Ruifang;Du, Jingying;Zhang, Manyu;Jiang, Wei;Sun, Qing;Mi, Rongsheng;Qin, Shuang;Wang, Quan;Geng, Xiaoling
关键词：
Toxoplasma gondii ; CRISPR/Cas9; thioredoxin reductase; rhoptry protein 16; immune escape; oxidative stress
