Improving the safety and efficacy of phage therapy from the perspective of phage-mammal interactions

文献类型： 外文期刊

第一作者： Zou, Geng

作者： Zou, Geng;He, Lijun;Rao, Jing;Song, Zhiyong;Du, Hu;Li, Runze;Wang, Wenjing;Zhou, Yang;Liang, Lu;Chen, Huanchun;Li, Jinquan;Zou, Geng;He, Lijun;Rao, Jing;Li, Runze;Li, Jinquan;Song, Zhiyong;Wang, Wenjing;Liang, Lu;Li, Jinquan;Li, Jinquan

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关键词： phage; interactions in phage-human; immune response; phage therapy; virome; microbiome

期刊名称：FEMS MICROBIOLOGY REVIEWS （ 影响因子：11.3； 五年影响因子：17.7 ）

ISSN： 0168-6445

年卷期： 2023 年 47 卷 4 期

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收录情况： SCI

摘要： A review on phage-mammal interaction mechanisms, phage-induced responses, and the factors that influence these interactions from the perspective of improving safety and efficacy of phage therapy. Phage therapy has re-emerged as a promising solution for combating antimicrobial-resistant bacterial infections. Increasingly, studies have revealed that phages possess therapeutic potential beyond their antimicrobial properties, including regulating the gut microbiome and maintain intestinal homeostasis, as a novel nanocarrier for targeted drug delivery. However, the complexity and unpredictability of phage behavior during treatment pose a significant challenge in clinical practice. The intricate interactions established between phages, humans, and bacteria throughout their long coexistence in the natural ecosystem contribute to the complexity of phage behavior in therapy, raising concerns about their efficacy and safety as therapeutic agents. Revealing the mechanisms by which phages interact with the human body will provide a theoretical basis for increased application of promising phage therapy. In this review, we provide a comprehensive summary of phage-mammal interactions, including signaling pathways, adaptive immunity responses, and phage-mediated anti-inflammatory responses. Then, from the perspective of phage-mammalian immune system interactions, we present the first systematic overview of the factors affecting phage therapy, such as the mode of administration, the physiological status of the patient, and the biological properties of the phage, to offer new insights into phage therapy for various human diseases.

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