FABP4 mediates endoplasmic reticulum stress and autophagy to regulate endometrial epithelial cell function during early sheep gestation

文献类型： 外文期刊

第一作者： Song, Meijun

作者： Song, Meijun;Hao, Kexing;Qi, Fenghua;Wang, Jing;Hu, Guangdong;Zhao, Wenjuan;Wang, Zhengrong

作者机构：

关键词： Autophagy; Endometrial epithelial cells; Endoplasmic reticulum stress; Fatty acid-binding protein; Implantation

期刊名称：JOURNAL OF REPRODUCTION AND DEVELOPMENT （ 影响因子：1.8； 五年影响因子：2.0 ）

ISSN： 0916-8818

年卷期： 2023 年 69 卷 6 期

页码：

收录情况： SCI

摘要： Dynamic changes in the endometrium are crucial for establishing early pregnancy in ruminants. Blastocyst elongation and implantation require hormones and nutrients to be secreted from the maternal endometrium. The fatty acid-binding protein FABP4 is a widely expressed fatty acid transport protein that promotes cell proliferation, migration, and invasion and is involved in conceptus implantation. However, the mechanism underlying the functional regulation of endometrial epithelial cells (EECs) by FABP4 during ovine peri-implantation remains unclear. We simulated hormonal changes in vitro in sheep EECs (SEECs) during the peri-implantation period and found that it elevated FABP4 expression. FABP4 inhibition significantly reduced cell migration, endoplasmic reticulum stress, and autophagy, suggesting that FABP4 regulates endometrial function in sheep. Moreover, the FABP4 inhibitor BMS309403 counteracted hormone-mediated functional changes in SEECs, and an endoplasmic reticulum stress activator and autophagy inhibitor reversed the abnormal secretion of prostaglandins induced by FABP4 inhibition. These results suggest that FABP4 affects ovine endometrial function during early gestation by regulating endoplasmic reticulum stress and autophagy in SEECs.

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