From homeostasis to defense: Exploring the role of selective autophagy in innate immunity and viral infections

文献类型： 外文期刊

第一作者： Huang, Mengyao

作者： Huang, Mengyao;Zhang, Wei;Yang, Yang;Shao, Wenhua;Wang, Jiali;Cao, Weijun;Zhu, Zixiang;Yang, Fan;Zheng, Haixue;Huang, Mengyao;Zhang, Wei;Yang, Yang;Shao, Wenhua;Wang, Jiali;Cao, Weijun;Zhu, Zixiang;Yang, Fan;Zheng, Haixue

作者机构：

关键词： Autophagy; Selective autophagy; Cargo receptor; Innate immunity; Viral infection

期刊名称：CLINICAL IMMUNOLOGY （ 影响因子：8.6； 五年影响因子：5.7 ）

ISSN： 1521-6616

年卷期： 2024 年 262 卷

页码：

收录情况： SCI

摘要： The process of autophagy, a conservative evolutionary mechanism, is responsible for the removal of surplus and undesirable cytoplasmic components, thereby ensuring cellular homeostasis. Autophagy exhibits a remarkable level of selectivity by employing a multitude of cargo receptors that possess the ability to bind both ubiquitinated cargoes and autophagosomes. In the context of viral infections, selective autophagy plays a crucial role in regulating the innate immune system. Notably, numerous viruses have developed strategies to counteract, evade, or exploit the antiviral effects of selective autophagy. This review encompasses the latest research progress of selective autophagy in regulating innate immunity and virus infectious.

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