A Semliki Forest virus replicon vectored DNA vaccine expressing the E2 glycoprotein of classical swine fever virus protects pigs from lethal challenge
文献类型： 外文期刊
第一作者： Li, Na
作者： Li, Na;Qiu, Hua-Ji;Zhao, Jian-Jun;Li, Yan;Wang, Ming-Jie;Lu, Bao-Wei;Han, Cheng-Gang;Hou, Qiang;Wang, Zhong-Hua;Gao, Hui;Peng, Wu-Ping;Li, Guo-Xin;Zhu, Qing-Hu;Tong, Guang-Zhi
作者机构：
期刊名称：VACCINE （ 影响因子：3.641； 五年影响因子：3.816 ）
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收录情况： SCI
摘要： Classical swine fever virus (CSFV) causes significant losses in pig industry in many countries in Asia and Europe. The E2 glycoprotein of CSFV is the main target for neutralizing antibodies. Recently, the replicon of alphaviruses, such as Semliki Forest virus (SFV), has been developed as replicative expression vectors for gene delivery. In this study, we constructed a plasmid DNA based on SFV replicon encoding the E2 glycoprotein of CSFV and evaluated its efficacy in rabbits and pigs. The results showed that the animals immunized with the DNA vaccine developed CSFV-specific neutralizing antibodies and were protected from virulent or lethal challenge. This demonstrates that the SFV replicon-derived DNA vaccine can be a potential marker vaccine against CSFV infections.
分类号： R194
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