Distinct fungal communities affecting opposite galanthamine accumulation patterns in two Lycoris species

文献类型： 外文期刊

第一作者： Wang, Ziying

作者： Wang, Ziying;Wang, Ren;Xu, Sheng;Zhou, Jiayu;Yuan, Jie;Wang, Ren;Xu, Sheng;Zhou, Jiayu

作者机构：

关键词： Fungal endophytes; Galanthamine; ITS amplicon sequencing; Lycoris aurea; Lycoris radiata; Mechanisms

期刊名称：MICROBIOLOGICAL RESEARCH （ 影响因子：6.9； 五年影响因子：7.2 ）

ISSN： 0944-5013

年卷期： 2024 年 286 卷

页码：

收录情况： SCI

摘要： Lycoris radiata is the main source of galanthamine, a clinical drug used in Alzheimer's disease; however, the galanthamine content in L. radiata is low. Lycoris aurea is another Lycoris species with high galanthamine content. Fungal endophytes can enhance plant secondary metabolite accumulation; thus, we compared the fungal communities in these two Lycoris species to identify certain fungal taxa in L. aurea capable of enhancing galanthamine accumulation. Several fungal endophytes, which were enriched in, exclusively isolated from L. aurea, or showed significant correlations with galanthamine, were demonstrated to enhance the accumulation of only galanthamine but no other Amaryllidaceae alkaloids (AAs) in L. radiata. These fungal endophytes mainly upregulated the downstream genes in the biosynthesis pathways of AAs in L. radiata, suggesting that they may allocate more precursors for galanthamine biosynthesis. This study demonstrated that fungal endophytes from L. aurea with higher galanthamine content can specifically enhance the accumulation of this medicinal alkaloid in other Lycoris species, thereby increasing the galanthamine source and reducing galanthamine separation and purification costs. This study broadens our understanding of the complex interactions between plant secondary metabolites and fungal endophytes.

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