Thyroid Transcriptomic Profiling Reveals the Follicular Phase Differential Regulation of lncRNA and mRNA Related to Prolificacy in Small Tail Han Sheep with Two FecB Genotypes

文献类型： 外文期刊

第一作者： Chang, Cheng

作者： Chang, Cheng;He, Xiaoyun;Di, Ran;Wang, Xiangyu;Chu, Mingxing;Chang, Cheng;Han, Miaoceng;Liang, Chen

作者机构：

关键词： lncRNAs; RNA-Seq; thyroid; prolificacy; sheep

期刊名称：GENES （ 影响因子：4.141； 五年影响因子：4.474 ）

ISSN：

年卷期： 2022 年 13 卷 5 期

页码：

收录情况： SCI

摘要： Long non-coding RNA (lncRNA) accounts for a large proportion of RNA in animals. The thyroid gland has been established as an important gland involved in animal reproduction, however, little is known of its gene expression patterns and potential roles in the sheep. Herein, RNA-Seq was used to detect reproduction-related differentially expressed lncRNAs (DELs) and mRNAs (DEGs) in the follicular phase (FT) FecB(BB) (MM) and FecB(B++) (ww) genotypes of Small Tail Han (STH) sheep thyroids. Overall, 29 DELs and 448 DEGs in thyroid between MM and ww sheep were screened. Moreover, GO and KEGG enrichment analysis showed that targets of DELs and DEGs were annotated in biological transitions, such as cell cycle, oocyte meiosis and methylation, which in turn affect reproductive performance in sheep. In addition, we constructed co-expression and networks of lncRNAs-mRNAs. Specifically, XLOC 075176 targeted MYB, XLOC 014695 targeted VCAN, 106991527 targeted CASR, XLOC 075176 targeted KIFC1, XLOC 360232 targeted BRCA2. All these differential lncRNAs and mRNAs expression profiles in the thyroid provide a new resource for elucidating the regulatory mechanism underlying STH sheep prolificacy.

分类号：

  • 相关文献
作者其他论文 更多>>

微信小程序