2-O-beta-D-Glucopyranosyl-L-ascorbic acid, an ascorbic acid derivative isolated from the fruits of Lycium barbarum L., ameliorates high fructose-induced neuroinflammation in mice: involvement of gut microbiota and leaky gutWei

文献类型： 外文期刊

第一作者： Dong, Wei

作者： Dong, Wei;Peng, Yujia;Chen, Guijie;Xie, Zhiyong;Xu, Weiqi;Zhou, Wangting;Sun, Yi;Zeng, Xiaoxiong;Mi, Jia;Lu, Lu;Cao, Youlong;Yan, Yamei

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关键词： Neuroinflammation; Gut microbiota; Leaky gut; Lipopolysaccharide; Fecal microbiome transplantation; 2O-beta-D-Glucopyranosyl-L-ascorbic acid

期刊名称：FOOD SCIENCE AND HUMAN WELLNESS （ 影响因子：7.0； 五年影响因子：8.3 ）

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年卷期： 2024 年 13 卷 1 期

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收录情况： SCI

摘要： Western diet (rich in highly refined sugar and fat) can induce a range of metabolic dysfunctions in animals and humans, including neuroinflammation and cognitive function decline. Neuroinflammation and cognitive impairment, two critical pathological characteristics of Alzheimer's disease, have been closely associated with microbial alteration via the gut-brain axis. Thus, the present study aimed to investigate the influence of 2-O-beta-D-glucopyranosyl-L-ascorbic acid (AA-2 beta G) isolated from the fruits of Lycium barbarum on preventing the high-fructose diet (HFrD) induced neuroinflammation in mice. It was found that AA-2 beta G prevented HFrD-induced cognitive deficits. AA-2 beta G also predominantly enhanced the gut barrier integrity, decreased lipopolysaccharide entry into the circulation, which subsequently countered the activation of glial cells and neuroinflammatory response. These beneficial effects were transmissible by horizontal fecal microbiome transplantation, transferring from AA-2 beta G fed mice to HFrD fed mice. Additionally, AA-2 beta G exerted neuroprotective effects involving the enrichment of Lactobacillus and Akkermansia, potentially beneficial intestinal bacteria. The present study provided the evidence that AA-2 beta G could improve indices of cognition and neuroinflammmation via modulating gut dybiosis and preventing leaky gut. As a potential functional food ingredient, AA-2 beta G may be applied to attenuate neuroinflammation associated with Western-style diets. (c) 2024 Beijing Academy of Food Sciences. Publishing services by Tsinghua University Press. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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