Reprogramming of phytopathogen transcriptome by a non-bactericidal pesticide residue alleviates its virulence in rice

文献类型： 外文期刊

第一作者： Matsumoto, Haruna

作者： Matsumoto, Haruna;Qian, Yuan;Fan, Xiaoyan;Qiao, Kun;Li, Meng;Shen, Peilin;Wang, Qiangwei;Yu, Yunlong;Wang, Mengcen;Matsumoto, Haruna;Qian, Yuan;Fan, Xiaoyan;Qiao, Kun;Li, Meng;Shen, Peilin;Wang, Qiangwei;Yu, Yunlong;Wang, Mengcen;Matsumoto, Haruna;Wang, Qiangwei;Yu, Yunlong;Wang, Mengcen;Fan, Xiaoyan;Cernava, Tomislav;Wang, Mengcen;Chen, Sunlu;Nie, Yanxia;Xiang, Dandan;Zhang, Xinzhong;Guo, Bo;Shen, Peilin

作者机构：

关键词： Phytopathogen; Virulence factor; Transcriptome reprogramming; Agrochemical; Pesticide; Rice

期刊名称：FUNDAMENTAL RESEARCH （ 影响因子：6.2； 五年影响因子：6.2 ）

ISSN： 2096-9457

年卷期： 2022 年 2 卷 2 期

页码：

收录情况： SCI

摘要： Bacteria equipped with virulence systems based on highly bioactive small molecules can circumvent their host???s defense mechanisms. Pathogens employing this strategy are currently threatening global rice production. In the present study, variations in the virulence of the highly destructive Burkholderia plantarii were observed in different rice-producing regions. The environment-linked variation was not attributable to any known host-related or external factors. Co-occurrence analyses indicated a connection between reduced virulence and 5-Amino-1,3,4-thiadiazole-2-thiol (ATT), a non-bactericidal organic compound. ATT, which accumulates in rice plants during metabolization of specific agrochemicals, was found to reduce virulence factor secretion by B. plantarii up to 88.8% and inhibit pathogen virulence by hijacking an upstream signaling cascade. Detailed assessment of the newly discovered virulence inhibitor resulted in mechanistic insights into positive effects of ATT accumulation in plant tissues. Mechanisms of virulence alleviation were deciphered by integrating high-throughput data, gene knockout mutants, and molecular interaction assays. TroK, a histidine protein kinase in a two-component system that regulates virulence factor secretion, is likely the molecular target antagonized by ATT. Our findings provide novel insights into virulence modulation in an important plant-pathogen system that relies on the host???s metabolic activity and subsequent signaling interference.

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