Protective effects of polysaccharide from Artocarpus heterophyllus Lam. (jackfruit) pulp on non-alcoholic fatty liver disease in high-fat diet rats via PPAR and AMPK signaling pathways

文献类型： 外文期刊

第一作者： Zeng, Shunjiang

作者： Zeng, Shunjiang;Chen, Yuzi;Wei, Chenxi;Tan, Lehe;Zhang, Yanjun;Xu, Fei;Zhu, Kexue;Wu, Gang;Zeng, Shunjiang;Li, Chuan;Cao, Jun;Chen, Yuzi;Wei, Chenxi;Zhang, Yanjun;Xu, Fei;Zhu, Kexue

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关键词： Artocarpus heterophyllus Lam; polysaccharide; Liver function; Non-alcoholic fatty liver disease; Signaling pathways

期刊名称：JOURNAL OF FUNCTIONAL FOODS （ 影响因子：5.223； 五年影响因子：5.178 ）

ISSN： 1756-4646

年卷期： 2022 年 95 卷

页码：

收录情况： SCI

摘要： A polysaccharide from jackfruit pulp (JFP-Ps) has been found to exhibit various types of bioactivities. This study aimed to investigate the effects and potential mechanisms of JFP-Ps on non-alcoholic fatty liver disease (NAFLD) induced by high-fat diet in rats. The pathological changes in the liver and liver function were determined using hematoxylin-eosin staining and biochemical analysis. RT-qPCR and Western blots were employed to study the expression of proteins associated with lipid metabolism and proinflammatory cytokines. Results showed that JFP-Ps reduced liver weight and liver index, and influenced liver function in high-fat diet rats. Furthermore, JFP-Ps up-regulated the lipolytic genes (PPAR alpha, LPL, CPT1, HSL) expression, downregulated the expression of lipogenic genes (SREBP-1c, ACC, FAS) and proinflammatory cytokines (TNF-alpha, IL-6) genes. JFP-Ps increased the protein expression of p-AMPK, and decreased the protein expression of SREBP-1c and AMPK. These results revealed that JFP-Ps might improve liver function and alleviate NAFLD through activating PPAR and AMPK signaling pathways.

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