Administration with Quinoa Protein Reduces the Blood Pressure in Spontaneously Hypertensive Rats and Modifies the Fecal Microbiota

文献类型： 外文期刊

第一作者： Guo, Huimin

作者： Guo, Huimin;Hao, Yuqiong;Fan, Xin;Yang, Xiushi;Ren, Guixing;Guo, Huimin;Fan, Xin;Richel, Aurore;Everaert, Nadia

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关键词： antihypertension; gastrointestinal digestion; ACE inhibitory peptides; gut dysbiosis; microbiota modification

期刊名称：NUTRIENTS （ 影响因子：5.719； 五年影响因子：6.352 ）

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年卷期： 2021 年 13 卷 7 期

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收录情况： SCI

摘要： Despite the well-established role of quinoa protein as the source of antihypertensive peptides through in vitro enzymolysis, there is little evidence supporting the in vivo antihypertensive effect of intact quinoa protein. In this study, in vivo study on spontaneously hypertensive rats (SHRs) was conducted by administering quinoa protein for five weeks. Gastrointestinal content identification indicated that many promising precursors of bioactive peptides were released from quinoa protein under gastrointestinal processing. Quinoa protein administration on SHRs resulted in a significant decrease in blood pressure, a significant increase in alpha diversity, and microbial structure alternation towards that in non-hypertension rats. Furthermore, blood pressure was highly negatively correlated with the elevated abundance of genera in quinoa protein-treated SHRs, such as Turicibacter and Allobaculum. Interestingly, the fecal microbiota in quinoa protein-treated SHRs shared more features in the composition of genera with non-hypertension rats than that of the captopril-treated group. These results indicate that quinoa protein may serve as a potential candidate to lower blood pressure and ameliorate hypertension-related gut dysbiosis.

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