Genomic Characteristics of Feline Anelloviruses Isolated from Domestic Cats in Shanghai, China

文献类型： 外文期刊

第一作者： Gao, Jun

作者： Gao, Jun;Liu, Chengqian;Yi, Jianzhong;Shi, Ying;Li, Hong;Liu, Huili

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关键词： viral metagenomics; feline anelloviruses; phylogenetic analysis

期刊名称：VETERINARY SCIENCES （ 影响因子：2.4； ）

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年卷期： 2023 年 10 卷 7 期

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收录情况： SCI

摘要： Simple Summary A viral metagenomic study of domestic cat feces revealed a high prevalence of feline anelloviruses (FcTTV) infection in domestic cats in Shanghai, China. By comparing the full-length sequences of the five Shanghai FcTTV variants, the study revealed the genomic features of the Shanghai FcTTV variants and identified recombination events between the variants. Viral metagenomics techniques allow the high-throughput discovery of possible pathogens carried by companion animals from their feces and other excreta. In this study, the viral metagenomics of 22 groups of fecal samples from domestic cats revealed a high prevalence of feline anelloviruses (FcTTV) infection in domestic cats in Shanghai, China. Serum samples from 30 cat individuals were further detected by polymerase chain reaction, and an average positive rate of 36.67% (11/30) of FcTTV infection was found. Next, the full-length sequences of five Shanghai FcTTV variants were obtained and submitted to GenBank with access numbers OP186140 to OP186144. Phylogenetic analysis indicates that the Shanghai FcTTV variants have relatively consistent genomic characteristics, with two variants from Zhejiang 2019 and one variant from the Czech Republic 2010. The recombination event analysis of the variants showed that one variant (OP186141_SH-02) had a primary parental sequence derived from a variant (KM229764) from the Czech Republic in 2010, while the secondary parental sequence was derived from OP186140_SH-01. The results revealed that FcTTV infection is prevalent in domestic cats and that the use of viral metagenomics to rapidly identify some infecting viruses whose hosts lack clinical features would be an effective approach.

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