Identification and characterization of a novel protective antigen, SeseC_00396 of Streptococcus equi ssp. Zooepidemicus

文献类型： 外文期刊

第一作者： Yi, Li

作者： Yi, Li;Yang, Weiping;Yi, Li;Li, Jinpeng;Wang, Yang;Li, Jinpeng;Wang, Yang;Wang, Shaohui

作者机构：

关键词： Streptococcus equi ssp. Zooepidemicus; Immune protection; Immunogen; Vaccine

期刊名称：THAI JOURNAL OF VETERINARY MEDICINE （ 影响因子：0.281； 五年影响因子：0.465 ）

ISSN： 0125-6491

年卷期： 2021 年 51 卷 2 期

页码：

收录情况： SCI

摘要： Streptococcus equi ssp. zooepidemicus (SEZ) is responsible for a wide variety of infections in many animal species. Studies aimed at developing safe and effective vaccines against SEZ infections are thus of great interest. SeseC_00396 was a novel protein identified in the previous study. In this study, recombinant SeseC_00396 of SEZ was expressed and showed a strong immunoreactivity with mini-pig convalescent sera. Studies in mice have revealed that the recombinant protein induced a marked antibody response which was associated with protection against SEZ infection. The hyperimmune sera against SeseC_00396 could efficiently kill the bacteria. In addition, it was also found that anti-SeseC_00396 antibodies can significantly inhibit the formation of SEZ biofilm. Data from this study suggests that SeseC_00396 identified in SEZ may represent immunogens of interest for vaccine development.

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