文献类型： 外文期刊

第一作者： Yang Ruining

作者： Yang Ruining;Xie Fei;Xie Tianpeng;Tang Linhuan;Zhou Hao;Ding Zhongtao;Li Hongtao;Li Hongtao;Ding Zhongtao;Yang Ruining

作者机构：

关键词： Penicillium sp.; Multioxidized polyketides; Secondary metabolite; Anti-acetylcholinesterase activity; PTP1B inhibitory activity

期刊名称：CHINESE JOURNAL OF NATURAL MEDICINES （ 影响因子：4.9； 五年影响因子：4.8 ）

ISSN： 2095-6975

年卷期： 2024 年 22 卷 11 期

页码：

收录情况： SCI

摘要： Three novel, highly oxygenated polyketides, multioketides A-C (1-3), and three previously described multioxidized aromatic polyketides (4-6), were isolated from an endophytic Penicillium sp. YUD17006 associated with Gastrodia elata. Their chemical structures were elucidated using extensive spectroscopic data, electronic circular dichroism calculations, and single X-ray diffraction analysis. All metabolites were characterized by a typical alpha,beta-unsaturated ketone fragment and exhibited a high degree of oxidation. Multioketides A and B were identified as a pair of epimers featuring a rare dihydroisobenzofuranone core. Multioketide C possessed a novel 5/6/6/6 heterotetracyclic chemical architecture with unusual 1,4-dioxin functionalities. Plausible biosynthetic pathways for 1-6 were proposed. Additionally, compound 3 demonstrated weak inhibitory activities against both acetylcholinesterase and protein tyrosine phosphatase 1B.

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