Thifluzamide exposure induced neuro-endocrine disrupting effects in zebrafish (Danio rerio)

文献类型： 外文期刊

第一作者： Yang, Yang

作者： Yang, Yang;Chang, Jinhe;Ma, Hao;Li, Yuanbo;Zheng, Yongquan;Wang, Donghui

作者机构：

关键词： Thifluzamide; Zebrafish embryo; Neurotoxicity; Thyroid disruption; Development

期刊名称：ARCHIVES OF TOXICOLOGY （ 影响因子：5.153； 五年影响因子：6.352 ）

ISSN： 0340-5761

年卷期： 2021 年 95 卷 12 期

页码：

收录情况： SCI

摘要： Thifluzamide is widely used fungicide and frequently detected in aquatic system. In this study, the toxicity of fungicide thifluzamide to non-targeted aquatic organisms was investigated for neuroendocrine disruption potentials. Here, zebrafish embryos were exposed to a series of concentrations of thifluzamide for 6 days. The results showed that both the development of embryos/larvae and the behavior of hatched larvae were significantly affected by thifluzamide. Importantly, the decreased activity of acetylcholinesterase (AchE) and the increased contents of neurotransmitters such as serotonin (5-HT) and norepinephrine (NE), along with transcriptional changes of nervous system related genes were observed following 4 days exposure to thifluzamide. Besides, the decreased contents of triiodothyronine (T3) and thyroxine (T4) in whole body, as well as significant expression alteration in hypothalamic-pituitary-thyroid (HPT) axis associated genes were discovered in zebrafish embryos after 4 days of exposure to thifluzamide. Our results clearly demonstrated that zebrafish embryos exposed to thifluzamide could disrupt neuroendocrine, compromise behavior and induce developmental abnormality, suggesting impact of this fungicide on developmental programming in zebrafish.

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