Foot and mouth disease vaccine efficacy in Africa: a systematic review and meta-analysis

文献类型： 外文期刊

第一作者： Wubshet, Ashenafi Kiros

作者： Wubshet, Ashenafi Kiros;Zhou, Luoyi;Sun, Yuefeng;Ding, Yaozhong;Zhang, Jie;Wubshet, Ashenafi Kiros;Werid, Gebremeskel Mamu;Teklue, Teshale;Zhou, Luoyi;Liu, Jinjin;Liu, Yongsheng;Zhang, Jie;Bayasgalan, Chimedtseren;Tserendorj, Ariunaa;Heath, Livio;Wang, Wenxiu;Zaberezhny, Alexei D.

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关键词： FMDV; FMD vaccine; efficacy; effectiveness; Africa

期刊名称：FRONTIERS IN VETERINARY SCIENCE （ 影响因子：2.6； 五年影响因子：3.1 ）

ISSN：

年卷期： 2024 年 11 卷

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收录情况： SCI

摘要： Background: Several factors, such as diverse serotypes, vaccination methods, weak biosecurity, and animal movements, contribute to recurrent Foot-and-Mouth Disease Virus (FMDV) outbreaks in Africa, establishing endemicity. These outbreaks cost over $2 billion annually, prompting a high-priority focus on FMDV vaccination. Despite extensive efforts, vaccine efficacy varies. This study aims to evaluate routine foot and mouth disease (FMD) vaccines in Africa via systematic review and meta-analysis. Methods: A systematic review and meta-analysis were carried out following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Meta-analysis was conducted to assess the efficacy of FMDV vaccination using the meta for package of R. Results: Vaccinated animals have roughly a 69.3% lower chance of FMDV infection compared to unvaccinated animals, as indicated by the pooled results from the random-effects model, which showed a risk ratio (RR) of 0.3073. There was a statistically significant heterogeneity (p < 0.05) across all of the included articles. Conclusion: Overall findings suggest that if properly planned and implemented, FMDV vaccination programs and strategies in Africa could help control the spread of the disease throughout the continent and beyond.

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