Roles and regulation of Aquaporin-3 in maintaining the gut health: an updated review

文献类型： 外文期刊

第一作者： Zhu, Cui

作者： Zhu, Cui;Nie, Xiaoyan;Lu, Qi;Bai, Yinshan;Jiang, Zongyong

作者机构：

关键词： Aquaporin 3; gut health; barrier function; inflammation; oxidative stress; autophagy

期刊名称：FRONTIERS IN PHYSIOLOGY （ 影响因子：4.0； 五年影响因子：4.7 ）

ISSN：

年卷期： 2023 年 14 卷

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收录情况： SCI

摘要： Aquaporin-3 (AQP3) is a predominant water channel protein expressed in the intestine, and plays important roles in the gut physiology and pathophysiology due to its permeability to water, glycerol and hydrogen peroxide. In this review, we systematically summarized the current understanding of the expression of AQP3 in the intestine of different species, and focused on the potential roles of AQP3 in water transport, different types of diarrhea and constipation, intestinal inflammation, intestinal barrier function, oxidative stress, and autophagy. These updated findings have supported that AQP3 may function as an important target in maintaining gut health of human and animals.

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