Polylactic acid nanoparticles for co-delivery of dinotefuran and avermectin against pear tree pests with improved effective period and enhanced bioactivity

文献类型： 外文期刊

第一作者： An, Changcheng

作者： An, Changcheng;Cui, Jianxia;Huang, Bingna;Li, Ningjun;Jiang, Jiajun;Shen, Yue;Wang, Chong;Zhan, Shenshan;Zhao, Xiang;Li, Xingye;Sun, Changjiao;Cui, Bo;Wang, Chunxin;Gao, Fei;Zeng, Zhanghua;Cui, Haixin;Wang, Yan;Yu, Qin;Zhang, Runxiang

作者机构：

关键词： Dinotefuran; Avermectin; Polylactic acid; Co-delivery nanoparticles; Pesticide utilization rate

期刊名称：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES （ 影响因子：8.2； 五年影响因子：7.8 ）

ISSN： 0141-8130

年卷期： 2022 年 206 卷

页码：

收录情况： SCI

摘要： Pesticide compounding technology for disease and pest control emerges as an effective way to increase the effectiveness of pesticides while reducing pesticides resistance. Nanomaterials and encapsulation technology have offered a new insight into preparing efficient pesticide formulations, especially constructing a co-delivery nanoparticle for synergistic pesticides. In this study, a dinotefuran/avermectin co-delivery nanoparticles (DACNPs) against pear tree pests with polylactic acid (PLA) as the wall material were constructed by double-emulsion method combined with high-pressure homogenization technique. The drug content of the DACNPs was 39.1% with an average size of 245.7 +/- 4.2 nm and the mean polymer dispersity index (PDI) value was 0.123. The DACNPs showed high foliar retention and good spread performance on target leaves due to the nanoscale effect. The obtained DACNPs showed a better control effect on Grapholitha molesta Busck and Psylla chinensis Yang et Li compared with the commercial formulations, which could significantly prolong the effective duration and enhance the bioactivity with lower amounts and application frequency of pesticides. This study may provide new insights into developing novel pesticide formulations to improve the utilization rate of pesticides, reduce environmental pollution and minimize the cost of farming.

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