Functional Characterization and Toxicological Study of Cordyceps militaris in Weaned Pigs

文献类型： 外文期刊

第一作者： Li, Yanping

作者： Li, Yanping;Yu, Bing;Huang, Zhiqing;Luo, Yuheng;Zheng, Ping;Mao, Xiangbing;Yu, Jie;Luo, Junqiu;Yan, Hui;He, Jun;Li, Yanping;Yu, Bing;Huang, Zhiqing;Luo, Yuheng;Zheng, Ping;Mao, Xiangbing;Yu, Jie;Luo, Junqiu;Yan, Hui;He, Jun;Lu, Yang

作者机构：

关键词： Cordyceps militaris; weaned pigs; safety; growth performance

期刊名称：TOXINS （ 影响因子：4.0； 五年影响因子：4.5 ）

ISSN：

年卷期： 2024 年 16 卷 12 期

页码：

收录情况： SCI

摘要： Cordyceps militaris (CM), a well-known parasitic fungus that grows on the larvae of Lepidoptera, has a variety of pharmacological activities. However, little is known about its safe dosage for animals, including pigs. To explore its effect on intestinal health and evaluate its safe dosage, 30 weaned pigs were randomly allotted to five groups and fed with a basal diet supplemented with different doses of CM for 42 days. The results showed that CM supplementation at 100 mg/kg increased the average daily weight gain (ADG) and significantly decreased the ratio of feed intake to gain (F:G) in the weaned pigs (p < 0.05). However, CM supplementation at a higher dose (1000 to 4000 mg/kg) had no effect on growth performance. CM supplementation at 100 mg/kg also increased the digestibility of gross energy and increased the ratio of villus height to crypt depth (V/C) in the duodenum and ileum (p < 0.05). Moreover, CM supplementation at 100 mg/kg increased the activities of catalase (CAT) and total antioxidant capacity (T-AOC), but decreased the concentration of malondialdehyde (MDA) in serum (p < 0.05). Importantly, histopathological studies of tissues (e.g., heart, liver, kidney, spleen, lungs, pancreas, thymus, mesenteric lymph nodes, stomach, and small intestine), organ indexes, major hematological parameters, and serum biochemical parameters were not affected upon CM supplementation. These results suggest that CM may have the potential to act as a safe and effective supplement to improve the growth performance and intestinal health of weaned pigs.

分类号：

  • 相关文献
作者其他论文 更多>>

微信小程序