Naturally occurring mutated infectious bursal disease virus of genotype A8B1 associated with bursa damage in China

文献类型： 外文期刊

第一作者： Jiang, Nan

作者： Jiang, Nan;Wang, Yulong;Zhang, Wenying;Niu, Xinxin;Gao, Yulong;Gao, Li;Li, Kai;Cui, Hongyu;Liu, Aijing;Pan, Qing;Liu, Changjun;Zhang, Yanping;Wang, Xiaomei;Qi, Xiaole;Wang, Xiaomei

作者机构：

关键词： Infectious bursal disease virus; ASB1; Genome; Mutant; Pathogenicity

期刊名称：VIRUS RESEARCH （ 影响因子：3.303； 五年影响因子：3.445 ）

ISSN： 0168-1702

年卷期： 2021 年 302 卷

页码：

收录情况： SCI

摘要： Infectious bursal disease virus (IBDV), the causative agent of infectious bursal disease (IBD), mainly damages the bursa of Fabricius, which is a central immune organ of birds. As an RNA virus, IBDV is prone to mutation owing to a combination of factors including natural selection pressure. In this study, a naturally occurring mutated IBDV associated with bursa damage was identified, IBDV-HeN20-7103 strain, in an infected chicken flock in central China. Its full-length genome was cloned, and sequence analysis showed that the IBDV-HeN20-7103 strain was located along with the attenuated IBDV, which corresponds to genotype A8B1 of the recently proposed classification scheme, on the branch of the phylogenetic tree. The amino acid sequence comparisons further highlighted the specific characteristics of IBDV-HeN20-7103 with mutation H253Q compared to the attenuated strain. Animal experiments showed that IBDV-HeN20-7103 could induce serious bursal lesions without mortality, which revealed a unique cause of disease in this flock. The identification of such a strain reaffirms the complexity of IBDV evolution and prevalence.

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