Development and application of a curcumin-cinnamon essential oil nanoemulsion agent against mycobacteria

文献类型： 外文期刊

第一作者： Lei, Zhihui

作者： Lei, Zhihui;Shi, Haisu;Zhang, Hongtai;Lei, Zhihui;Wang, Jinyao;Wang, Yutang;Zhang, Hongtai;Lei, Zhihui;Chen, Hong;Bi, Lijun;Ren, Yixuan;Zhang, Hongtai;Lin, Hu;Bi, Lijun

作者机构：

关键词： curcumin; cinnamon essential oil; nanoemulsion; aerosols; mycobacteria; Mycobacterium tuberculosis

期刊名称：FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY （ 影响因子：4.8； 五年影响因子：5.5 ）

ISSN： 2235-2988

年卷期： 2025 年 15 卷

页码：

收录情况： SCI

摘要： With the increasing prevalence of drug-resistant Mycobacterium tuberculosis (M. tuberculosis), the development of novel anti-mycobacterial agents has become urgent. In this study, a curcumin-cinnamon essential oil (Cur-CEO) nanoemulsion was developed with optimized preparation parameters, including a 10% CEO volume fraction, 7.5 minutes of ultrasonic treatment, and 350 W ultrasound power, yielding a particle size of 101.14 nm. The nanoemulsion demonstrated high encapsulation efficiency (90.2%) and stability, with a stability coefficient of 0.984. Structural analysis revealed a dense network structure of the nanoemulsion and amorphous forms of Cur and CEO, enhanced by hydrogen bonding and electrostatic interactions, which improved solubility and bioavailability. The Cur-CEO nanoemulsion exhibited potent antimicrobial activity against mycobacteria, demonstrating MIC values of 2 mu g/mL and 0.25 mu g/mL against Mycobacterium smegmatis and M. tuberculosis, respectively, representing a fourfold reduction compared to the CEO solution alone, owing to its ability to induce substantial damage to mycobacterial cell membranes and consequently enhance nucleic acid and protein leakage. Furthermore, the aerosol form of the nanoemulsion effectively inhibited both surface and airborne mycobacteria, with no significant changes in structural properties post-atomization. Lung deposition studies indicated that 75.6% of aerosol particles of the nanoemulsion reached the alveolar region, suggesting its potential as an inhalation agent. Additionally, the Cur-CEO nanoemulsion exhibited negligible effects on macrophage viability, maintaining a survival rate exceeding 85% even at concentrations up to 1250 ng/mL. These findings indicate that the Cur-CEO nanoemulsion, formulated using natural ingredients, holds significant promise as a food-grade antibacterial agent for the prevention and control of mycobacterial infections.

分类号：

  • 相关文献
作者其他论文 更多>>

微信小程序