Uncovering Molecular Mechanisms of Feed Efficiency in Pigs Through Multi-Omics Analysis of the Jejunum

文献类型： 外文期刊

第一作者： Zhang, Saixian

作者： Zhang, Saixian;Qi, Xiaolong;Li, Jingjin;Liu, Yuwen;Zhang, Saixian;Xiang, Yue;Jian, Yaobang;Zhao, Qiulin;Sun, Jiahui;Huang, Yi;Xu, Jing;Zheng, Zhuqing;Fu, Liangliang;Li, Xinyun;Zhang, Saixian;Xiang, Yue;Jian, Yaobang;Zhao, Qiulin;Sun, Jiahui;Huang, Yi;Xu, Jing;Zheng, Zhuqing;Fu, Liangliang;Li, Xinyun

作者机构：

关键词： feed efficiency; pigs; jejunum; RNA-seq; ATAC-seq; lipid metabolism; immune response

期刊名称：ANIMALS （ 影响因子：2.7； 五年影响因子：3.2 ）

ISSN： 2076-2615

年卷期： 2025 年 15 卷 2 期

页码：

收录情况： SCI

摘要： Feed efficiency (FE) is a crucial trait in pig production that influences both economic viability and environmental sustainability. The jejunum, an essential organ for nutrient absorption, plays a significant role in determining FE by affecting how pigs process and utilize feed. To explore the genetic and regulatory mechanisms behind FE, we conducted an integrative multi-omics study using RNA sequencing (RNA-seq) and ATAC sequencing (ATAC-seq) on pigs with high and low FE. By comparing gene expression and chromatin accessibility profiles in the jejunum, we identified key differentially expressed genes (DEGs) and differentially accessible regions (DARs) associated with lipid metabolism and immune function, both of which are critical pathways for efficient growth. Notably, we identified transcription factors such as GATA4 and EHF and genes like SCARB1 and GRXCR1 that may play regulatory roles in FE. Our findings provide novel insights into the molecular mechanisms governing FE in pigs, offering potential targets for genetic selection and nutritional interventions to enhance feed efficiency and sustainability in pig production.

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