Baicalin restore intestinal damage after early-life antibiotic therapy: the role of the MAPK signaling pathway

文献类型： 外文期刊

第一作者： Zhang, Shunfen

作者： Zhang, Shunfen;Tang, Shanlong;Liu, Zhengqun;Zhong, Ruqing;Chen, Liang;Zhang, Hongfu;Zhang, Shunfen;Lv, Huiyuan;Cai, Xueying;Liu, Zhengqun;Lv, Huiyuan

作者机构：

关键词： Baicalin; Intestinal damage; Energy metabolism; Calcium signaling pathway; MAPK signaling pathway

期刊名称：PHARMACOLOGICAL RESEARCH （ 影响因子：9.3； 五年影响因子：8.8 ）

ISSN： 1043-6618

年卷期： 2024 年 204 卷

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收录情况： SCI

摘要： Antibiotic related intestinal injury in early life affects subsequent health and susceptibility. Here, we employed weaned piglets as a model to investigate the protective effects of baicalin against early-life antibiotic exposureinduced microbial dysbiosis. Piglets exposed to lincomycin showed a marked reduction in body weight (p < 0.05) and deterioration of jejunum intestinal morphology, alongside an increase in antibiotic-resistant bacteria such as Staphylococcus, Dolosicoccus, Escherichia-Shigella, and Raoultella. In contrast, baicalin treatment resulted in body weights, intestinal morphology, and microbial profiles that closely resembled those of the control group (p > 0.05), with a significant increase in norank_f_Muribaculaceae and Prevotellaceae_NK3B31_group colonization compared with lincomycin group (p < 0.05). Further analysis through fecal microbial transplantation into mice revealed that lincomycin exposure led to significant alterations in intestinal morphology and microbial composition, notably increasing harmful microbes and decreasing beneficial ones such as norank_Muribaculaceae and Akkermansia (p < 0.05). This shift was associated with an increase in harmful metabolites and disruption of the calcium signaling pathway gene expression. Conversely, baicalin supplementation not only counteracted these effects but also enhanced beneficial metabolites and regulated genes within the MAPK signaling pathway (MAP3K11, MAP4K2, MAPK7, MAPK13) and calcium channel proteins (ORA13, CACNA1S, CACNA1F and CACNG8), suggesting a mechanism through which baicalin mitigates antibiotic-induced intestinal and microbial disturbances. These findings highlight baicalin's potential as a plant extract-based intervention for preventing antibiotic-related intestinal injury and offer new targets for therapeutic strategies.

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