Reduction of ROS-HIF1 alpha-driven glycolysis by taurine alleviates Streptococcus uberis infection

文献类型： 外文期刊

第一作者： Lan, Riguo

作者： Lan, Riguo;Zhou, Yuanyuan;Wang, Zhenglei;Fu, Shaodong;Gao, Yabing;Gao, Xing;Xu, Yuanyuan;Miao, Jinfeng;Zhang, Jinqiu;Han, Xiangan;Phouthapane, Vanhnaseng

作者机构：

期刊名称：FOOD & FUNCTION （ 影响因子：6.317； 五年影响因子：6.375 ）

ISSN： 2042-6496

年卷期： 2022 年 13 卷 4 期

页码：

收录情况： SCI

摘要： Antibiotic-resistant strains of Streptococcus uberis (S. uberis) frequently cause clinical mastitis in dairy cows resulting in enormous economic losses. The regulation of immunometabolism is a promising strategy for controlling this bacterial infection. To investigate whether taurine alleviates S. uberis infection by the regulation of host glycolysis via HIF1 alpha, the murine mammary epithelial cell line (EpH4-Ev) and C57BL/6J mice were challenged with S. uberis. Our data indicate that HIF1 alpha-driven glycolysis promotes inflammation and damage in response to the S. uberis challenge. The activation of HIF1 alpha is dependent on mTOR-mediated ROS production. These results were confirmed in vivo. Taurine, an intracellular metabolite present in most animal tissues, has been shown to effectively modulate HIF1 alpha-triggered metabolic reprogramming and contributes to a reduction of inflammation, which reduces mammary tissue damage and prevents mammary gland dysfunction in S. uberis-induced mastitis. These data provide a novel putative prophylactic and therapeutic strategy for amelioration of dairy cow mastitis and bacterial inflammation.

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