Genetic basis and origin of coat color in Leiqiong cattle

文献类型： 外文期刊

第一作者： Luo, Fu-Nong

作者： Luo, Fu-Nong;Chen, Shu-Jun;Nanaei, Hojjat Asadollahpour;Wang, Xin-Yu;Li, Jie;Jiang, Yu;Luo, Fu-Nong;Chen, Shu-Jun;Wang, Xin-Yu;Li, Jie;Jiang, Yu;Nanaei, Hojjat Asadollahpour;Heller, Rasmus;Hu, De-Xiang;Cheng, Hong;Ni, Shi-Heng;Li, Mao;Dai, Xue-Lei

作者机构：

关键词： Genome-wide association studies; Indicine cattle; CORIN gene; Haplotype diversity; Introgression

期刊名称：ZOOLOGICAL RESEARCH （ 影响因子：4.7； 五年影响因子：4.7 ）

ISSN： 2095-8137

年卷期： 2025 年 46 卷 3 期

页码：

收录情况： SCI

摘要： Coat color polymorphism in domestic animals provides a robust framework for elucidating mechanisms of species adaptation, domestication, and genomic diversity. Leiqiong cattle, a representative indicine breed from southern China, are predominantly yellow-coated, although a subset exhibits a solid black phenotype. To determine the genetic basis of this variation, a genome-wide association study (GWAS) was performed in 212 Leiqiong bulls. A pronounced association signal was detected on chromosome 6 within the fifth intron of the CORIN gene, providing the first evidence of the potential influence of CORIN on bovine coat color variation. Integration of these results with publicly available genomic datasets and haplotype analyses indicated that the yellow coat phenotype is derived from Indian indicine ancestry, whereas the black coat phenotype emerged through introgression from wild bovine lineages and artificial hybridization with Wagyu cattle. Comparative analysis of Indian indicine cattle with divergent coat colors revealed distinct LEF1 haplotypes within a shared CORIN background, suggesting an ancient and complex domestication history underlying coat color variation. These findings provide direct evidence that introgression has shaped phenotypic variation in East Asian cattle and offer novel insights into the genetic architecture of pigmentation, with implications for future breeding strategies.

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