Effects of endogenous DHA milk and exogenous DHA milk on oxidative stress and cognition in SAMP8 mice

文献类型： 外文期刊

第一作者： Wang, Xiaodan

作者： Wang, Xiaodan;Zhu, Huiquan;Chen, Baorong;Zhang, Yumeng;Zhang, Shuwen;Pang, Xiaoyang;Lv, Jiaping;Wang, Xiaodan;Kok, Akke;van Knegsel, Ariette;Kemp, Bas;Lu, Jing;Jiang, Shilong

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关键词： DHA; Milk; Antioxidant; Cognition; Lipid-oxidative; Metabolites

期刊名称：BIOMEDICINE & PHARMACOTHERAPY （ 影响因子：7.5； 五年影响因子：6.8 ）

ISSN： 0753-3322

年卷期： 2024 年 174 卷

页码：

收录情况： SCI

摘要： In this study, Senescence Accelerated Mice (SAMP8) were supplemented with exogenous DHA milk, endogenous DHA milk, normal milk, or 0.9 % saline solution. Enzyme -linked immunosorbent assay (ELISA), gas chromatography (GC), ultra -performance liquid chromatography-electrospray ionization -tandem mass spectrometry (UPLC-ESI MS/MS), and Morris water maze were used to characterize the effects of diet on oxidative stress and cognition in SAMP8 mice. Supplementation endogenous DHA milk or exogenous DHA milk can enhance the antioxidant capacity of mice organs. Endogenous DHA milk increased the superoxide dismutase (SOD) activity of mice brain and serum than normal milk and 0.9 % saline solution (P <= 0.05), as well as increased SOD activity of mice liver and glutathione peroxidase (GSH-Px) activity of mice brain than normal milk (P <= 0.05). Exogenous DHA milk increased SOD activity of mice brain than normal milk and 0.9 % saline solution, as well as increased SOD activity of mice serum than 0.9 % saline solution (P <= 0.05). Several polar lipid relative content, such as 18:0/18:2 PS, 17:0 Ceramide, and 20:4 LPC in mice brain was affected by dietary supplementation with DHAcontaining milk. Lipid oxidation metabolites in mice brain were not affected by DHA-containing milk. Endogenous DHA milk increased the number of platform location crossing times of mice in the Morris water maze test, compared with Exogenous DHA milk, normal milk, and 0.9 % saline solution (P <= 0.05).

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