N6-methyladenosine RNA modification promotes viral genomic RNA stability and infection

文献类型： 外文期刊

第一作者： Zhang, Tianye

作者： Zhang, Tianye;Hu, Haichao;Wang, Ziqiong;Chen, Zhiqing;Feng, Huimin;Liu, Peng;Guo, Jun;Lu, Qisen;Zhong, Kaili;Liu, Jiaqian;Chen, Jianping;Yang, Jian;Shi, Chaonan;Chen, Feng;Zhang, Zhuo;Chen, ZhiHui;Yu, Jiancheng

作者机构：

期刊名称：NATURE COMMUNICATIONS （ 影响因子：17.694； 五年影响因子：17.763 ）

ISSN：

年卷期： 2022 年 13 卷 1 期

页码：

收录情况： SCI

摘要： Molecular manipulation of susceptibility (S) genes that are antipodes to resistance (R) genes has been adopted as an alternative strategy for controlling crop diseases. Here, we show the S gene encoding Triticum aestivum m(6)A methyltransferase B (TaMTB) is identified by a genome-wide association study and subsequently shown to be a positive regulator for wheat yellow mosaic virus (WYMV) infection. TaMTB is localized in the nucleus, is translocated into the cytoplasmic aggregates by binding to WYMV NIb to upregulate the m(6)A level of WYMV RNA1 and stabilize the viral RNA, thus promoting viral infection. A natural mutant allele TaMTB-SNP176C is found to confer an enhanced susceptibility to WYMV infection through genetic variation analysis on 243 wheat varieties. Our discovery highlights this allele can be a useful target for the molecular wheat breeding in the future. Wheat production is threatened by wheat yellow mosaic virus (WYMV). Here, via genome-wide association study, the authors report that a putative methyltransferase B positively regulates WYMV infection through enhancing viral genomic RNA stability by N6-methyladenosine RNA modification.

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