Effects of walnut seed coat polyphenols on walnut protein hydrolysates: Structural alterations, hydrolysis efficiency, and acetylcholinesterase inhibitory capacity

文献类型： 外文期刊

第一作者： Su, Guowan

作者： Su, Guowan;Chen, Jieqiong;Huang, Lin;Zhao, Mouming;Zhang, Jianan;Deng, Liuxin;Chen, Jieqiong;Zhang, Yehui;Zhao, Tiantian;Huang, Qingrong;Zhao, Tiantian;Zhao, Mouming;Zhao, Tiantian;Zeng, Xi

作者机构：

关键词： Walnut hydrolysates; Seed coat polyphenols; Structural alterations; Hydrolysis efficiency; AChE inhibition; Synergistic effects

期刊名称：FOOD CHEMISTRY （ 影响因子：8.8； 五年影响因子：8.6 ）

ISSN： 0308-8146

年卷期： 2024 年 437 卷

页码：

收录情况： SCI

摘要： The walnut meal is rich in nutrients such as protein from the kernel and polyphenolic compounds from the seed coat. However, the influences of seed coat polyphenols on walnut protein (WP) hydrolysis remained unclear. In this study, our findings indicated that polyphenols induced alterations in the secondary structure and amino acid composition of WP. These changes resulted in both a hindrance of hydrolysis and an enhancement of acetyl-cholinesterase (AChE) inhibition. Furthermore, four peptides of 119 identified peptides (LR, SF, FQ, and FR) were synthesized based on higher predicted bioactivity and Vina scores in silico. Among them, FQ showed interaction with amino acid residues in AChE through the formation of four pi-pi stacking bonds and two hydrogen bonds, resulting in the highest AChE inhibitory capacity. The combination index showed that chlorogenic acid derived from the seed coat and FQ at the molar ratio of 1:4 exhibited synergistic effects of AChE inhibition.

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