Determination of Quinolone Antibiotic Residues in Human Serum and Urine Using High-Performance Liquid Chromatography/Tandem Mass Spectrometry

文献类型： 外文期刊

第一作者： Wang, Xiaoli

作者： Wang, Xiaoli;Wei, Yunbo;Xu, Guiju;Li, Na;Feng, Jinhong;Zhao, Rusong;Guo, Tao

作者机构：

期刊名称：JOURNAL OF ANALYTICAL TOXICOLOGY （ 影响因子：3.367； 五年影响因子：3.21 ）

ISSN： 0146-4760

年卷期： 2019 年 43 卷 7 期

页码：

收录情况： SCI

摘要： Quinolone antibiotic residues may pose potential threat to human health. A rapid and sensitive method was developed for the determination of quinolone residues in human serum and urine. After solid phase extraction (SPE) process, eight quinolone residues were analyzed by high-performance liquid chromatography/tandem mass spectrometry (HPLC-MS/MS) using ciprofloxacin-d8 as the internal standard. The relative standard deviation of intra-day and inter-day precision for the eight quinolones were less than 7.52% and the accuracies ranged from 95.8% to 103% in human serum, and from 94.1% to 104% in human urine. The extraction recoveries for the eight quinolones varied from 80.2% to 113% in human serum and 83.4% to 117% in human urine. The limit of detection for the eight quinolones was 0.50-1.00 ng/mL. Quinolone antibiotic residues in human serum and urine from 12 volunteers were successfully analyzed with the validated method. The SPE-HPLC-MS/MS method was useful for accurate determination of quinolone antibiotic residues in human body.

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