Nagimycins A and B, Antibacterial Ansamycin-Related Macrolactams from Streptomyces sp. NA07423
文献类型： 外文期刊
第一作者： Guo, Zhi Kai
作者： Guo, Zhi Kai;Abulaizi, Ailiman;Xiong, Zi Jun;Zhang, Shi Qing;Guo, Zhi Kai;Abulaizi, Ailiman;Xiong, Zi Jun;Zhang, Shi Qing;Wang, Yong Chao;Tan, Ying Zi;Abulaizi, Ailiman;Shi, Jing;Yang, Yang;Yang, La Ying;Yang, Yang;Yang, La Ying
作者机构：
期刊名称：ORGANIC LETTERS （ 影响因子：5.2； 五年影响因子：4.9 ）
ISSN： 1523-7060
年卷期： 2023 年 25 卷 22 期
页码：
收录情况： SCI
摘要： Chemical investigation of Streptomyces sp. NA07423led to the discovery of two unreported macrolactams, nagimycins A(1) and B (2). Their structures were elucidatedby NMR, HRESIMS, X-ray crystallography, and comparison of experimentaland theoretical ECD spectra. The nagimycins have a unique butenolidemoiety rarely found in ansamycin antibiotics. Genome analysis revealedthe putative biosynthetic gene cluster for nagimycins, and a likelybiosynthetic pathway was proposed. Notably, compounds 1 and 2 exhibited potent antibacterial activity againsttwo pathogenic Xanthomonas bacteria.
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