Nagimycins A and B, Antibacterial Ansamycin-Related Macrolactams from Streptomyces sp. NA07423

文献类型: 外文期刊

第一作者: Guo, Zhi Kai

作者: Guo, Zhi Kai;Abulaizi, Ailiman;Xiong, Zi Jun;Zhang, Shi Qing;Guo, Zhi Kai;Abulaizi, Ailiman;Xiong, Zi Jun;Zhang, Shi Qing;Wang, Yong Chao;Tan, Ying Zi;Abulaizi, Ailiman;Shi, Jing;Yang, Yang;Yang, La Ying;Yang, Yang;Yang, La Ying

作者机构:

期刊名称:ORGANIC LETTERS ( 影响因子:5.2; 五年影响因子:4.9 )

ISSN: 1523-7060

年卷期: 2023 年 25 卷 22 期

页码:

收录情况: SCI

摘要: Chemical investigation of Streptomyces sp. NA07423led to the discovery of two unreported macrolactams, nagimycins A(1) and B (2). Their structures were elucidatedby NMR, HRESIMS, X-ray crystallography, and comparison of experimentaland theoretical ECD spectra. The nagimycins have a unique butenolidemoiety rarely found in ansamycin antibiotics. Genome analysis revealedthe putative biosynthetic gene cluster for nagimycins, and a likelybiosynthetic pathway was proposed. Notably, compounds 1 and 2 exhibited potent antibacterial activity againsttwo pathogenic Xanthomonas bacteria.

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