Integrated histopathological, lipidomic, and metabolomic profiles reveal mink is a useful animal model to mimic the pathogenicity of severe COVID-19 patients

文献类型： 外文期刊

第一作者： Song, Zhiqi

作者： Song, Zhiqi;Bao, Linlin;Deng, Wei;Liu, Jiangning;Lv, Qi;Liu, Mingya;Qi, Feifei;Chen, Ting;Deng, Ran;Li, Fengdi;Liu, Yunpeng;Wei, Qiang;Gao, Hong;Yu, Pin;Han, Yunlin;Zhao, Wenjie;Liang, Xujian;Qin, Chuan;Song, Zhiqi;Bao, Linlin;Deng, Wei;Liu, Jiangning;Lv, Qi;Liu, Mingya;Qi, Feifei;Chen, Ting;Deng, Ran;Li, Fengdi;Liu, Yunpeng;Wei, Qiang;Gao, Hong;Yu, Pin;Han, Yunlin;Zhao, Wenjie;Liang, Xujian;Qin, Chuan;Ren, Erjun;Zheng, Junjun;Yang, Fuhe

作者机构：

期刊名称：SIGNAL TRANSDUCTION AND TARGETED THERAPY （ 影响因子：38.104； 五年影响因子：35.13 ）

ISSN： 2095-9907

年卷期： 2022 年 7 卷 1 期

页码：

收录情况： SCI

摘要： Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is transmitted on mink farms between minks and humans in many countries. However, the systemic pathological features of SARS-CoV-2-infected minks are mostly unknown. Here, we demonstrated that minks were largely permissive to SARS-CoV-2, characterized by severe and diffuse alveolar damage, and lasted at least 14 days post inoculation (dpi). We first reported that infected minks displayed multiple organ-system lesions accompanied by an increased inflammatory response and widespread viral distribution in the cardiovascular, hepatobiliary, urinary, endocrine, digestive, and immune systems. The viral protein partially co-localized with activated Mac-2(+) macrophages throughout the body. Moreover, we first found that the alterations in lipids and metabolites were correlated with the histological lesions in infected minks, especially at 6 dpi, and were similar to that of patients with severe and fatal COVID-19. Particularly, altered metabolic pathways, abnormal digestion, and absorption of vitamins, lipids, cholesterol, steroids, amino acids, and proteins, consistent with hepatic dysfunction, highlight metabolic and immune dysregulation. Enriched kynurenine in infected minks contributed to significant activation of the kynurenine pathway and was related to macrophage activation. Melatonin, which has significant anti-inflammatory and immunomodulating effects, was significantly downregulated at 6 dpi and displayed potential as a targeted medicine. Our data first illustrate systematic analyses of infected minks to recapitulate those observations in severe and fetal COVID-19 patients, delineating a useful animal model to mimic SARS-CoV-2-induced systematic and severe pathophysiological features and provide a reliable tool for the development of effective and targeted treatment strategies, vaccine research, and potential biomarkers.

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