Genome-Wide Transcriptional Profiling of the Response of Staphylococcus aureus to Cryptotanshinone

文献类型： 外文期刊

第一作者： Feng, Haihua

作者： Feng, Haihua;Xiang, Hua;Liu, Guowen;Guo, Na;Wang, Xuelin;Wu, Xiuping;Deng, Xuming;Yu, Lu;Zhang, Jiyu

作者机构：

期刊名称：JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY （ 影响因子：3.169； 五年影响因子：3.132 ）

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收录情况： SCI

摘要： Staphylococcus aureus (S. aureus) strains with multiple antibiotic resistances are increasingly widespread, and new agents are required for the treatment of S. aureus. Cryptotanshinone (CT), a major tanshinone of medicinal plant Salvia miltiorrhiza Bunge, demonstrated effective in vitro antibacterial activity against all 21 S. aureus strains tested in this experiment. Arrymetrix GeneChips were utilized to determine the global transcriptional response of S. aureus ATCC 25923 to treatment with subinhibitory concentrations of CT. Transcriptome profiling indicated that the antibacterial action of CT may be associated with its action as active oxygen radical generator; S. aureus undergoes an oxygen-limiting state upon exposure to CT.

分类号： R3

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