Cyantraniliprole-mediated transgenerational hormesis in the invasive tomato pinworm, Tuta absoluta

文献类型： 外文期刊

第一作者： Ullah, Farman

作者： Ullah, Farman;Gul, Hina;Li, Xiaowei;Lu, Yaobin;Ullah, Farman;Lu, Yaobin;Guncan, Ali;Guedes, Raul Narciso C.;Desneux, Nicolas

作者机构：

关键词： biphasic concentration-response; diamide; RNAi; nanomaterial; sublethal effects; life table

期刊名称：PEST MANAGEMENT SCIENCE （ 影响因子：3.8； 五年影响因子：4.3 ）

ISSN： 1526-498X

年卷期： 2025 年

页码：

收录情况： SCI

摘要： BACKGROUND Hormesis, a biphasic dose-response phenomenon, is gaining recognition for its bioregulatory and practical implications. Invasive species present a critical context for studying hormesis, because sublethal population-level responses may facilitate establishment and spread, particularly when transgenerational effects are involved. The invasive South American tomato pinworm, Tuta absoluta Meyrick, a global agricultural pest, exemplifies this scenario. Despite its relevance, the role of hormesis, particularly in response to novel insecticides like cyantraniliprole, a second-generation anthranilic diamide widely used against lepidopteran pests, remains underexplored. Thus, using age-stage, two-sex life table analyses and nanocarrier-mediated RNA interference, we examined the sublethal effects of cyantraniliprole on T. absoluta.RESULTS Cyantraniliprole exhibited high toxicity to third-instar larvae, with a median lethal concentration (LC50) of 0.72 mg L-1 after 72 h of exposure. Sublethal and low lethal concentrations (LC10 and LC30) prolonged developmental times and reduced adult longevity and fecundity in exposed individuals. Intriguingly, exposure to LC10 in subsequent generations (F1 and F2) shortened developmental times and increased survival, reproduction and life table parameters, whereas exposure to LC30 significantly impaired these traits. Gene expression analyses revealed reduced levels of development and reproduction-related genes (Vg, VgR and JHBP) in parental insects but increased levels in F1 and F2 at LC10, whereas the levels of expression remained consistent at LC30. Overexpression of detoxification-related P450 genes (CYP4M116, CYP6AW1 and CYP9A307v2) persisted over generations, whereas nanomaterial-encapsulated dsRNA targeting these genes significantly increased susceptibility to cyantraniliprole.CONCLUSION Cyantraniliprole induces a transgenerational hormesis-like response in T. absoluta. These findings highlight the need to evaluate the hormetic-like effects when designing ecologically sound pest management strategies for this invasive pest species. (c) 2025 Society of Chemical Industry.

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