Preventive regulation of cellular heat stress injury by mung bean polyphenols revealed by multi-omics analysis

文献类型： 外文期刊

第一作者： Feng, Yuchao

作者： Feng, Yuchao;Suo, Decheng;Li, Xiaonan;Fan, Xia;Feng, Yuchao;Zhang, Shu;Fu, Tianxin;Wang, Changyuan

作者机构：

期刊名称：NPJ SCIENCE OF FOOD （ 影响因子：7.8； 五年影响因子：7.0 ）

ISSN：

年卷期： 2025 年 9 卷 1 期

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收录情况： SCI

摘要： Based on the Caco-2 cell heat stress model, the study explored the heat stress preventive regulatory mechanisms of key polyphenol fractions in mung bean by metabolomics and transcriptomics association analysis. Results Mung bean polyphenol intervention before heat stress significantly reduced the elevated expression level of heat shock protein 70 (HSP70) caused by 39 degrees C temperature. At the metabolic level, mung bean polyphenols could play a role in heat stress regulation by alleviating oxidative stress damage. At the gene level, mung bean polyphenols showed regulation of cell proliferation, differentiation, and DNA damage, with DUSP6 and NEURL3 as key regulatory genes. The correlation analysis showed that nucleotide metabolism, and oxidative phosphorylation metabolism were the key pathways in the regulation of mung bean polyphenols by heat stress. Then mung bean polyphenols can exert heat stress preventive activity through the regulation of cellular oxidative damage and energy metabolism. This study provides a good idea for the research and development of dietary intervention products for heat stress.

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