Gradual effects of gradient concentrations of perfluorooctane sulfonate on the antioxidant ability and gut microbiota of red claw crayfish ( Cherax quadricarinatus )

文献类型： 外文期刊

第一作者： Hong, Shuang

作者： Hong, Shuang;Song, Weiguo;Liu, Chengbin;Yao, Chunxia;Zhu, Chenxi;Han, Mingming;Jiang, Qichen;Lv, Weiwei;Jiang, Qichen;Hong, Shuang

作者机构：

关键词： Gut microbes; PFOS; Antioxidant response; Cherax quadricarinatus

期刊名称：SCIENCE OF THE TOTAL ENVIRONMENT （ 影响因子：9.8； 五年影响因子：9.6 ）

ISSN： 0048-9697

年卷期： 2024 年 931 卷

页码：

收录情况： SCI

摘要： Perfluorooctane sulfonate (PFOS) is a typical persistent organic pollutant that is characterized by environmental persistence, bioaccumulation, and toxicity. In this study, we investigated the gut microbial response of the red claw crayfish Cherax quadricarinatus after 28 days of exposure to 0 ng/L, 1 ng/L, 10 mu g/L, or 10 mg/L of PFOS as a stressor. We measured oxidative stress-related enzyme activities and expression of molecules related to detoxification mechanisms to evaluate the toxic effects of PFOS. We found that PFOS disturbed microbial homeostasis in the gut of C. quadricarinatus, resulting in increased abundance of the pathogen Shewanella and decreased abundance of the beneficial bacterium Lactobacillus. The latter especially disturbed amino acid transport and carbohydrate transport. We also found that the activities of glutathione S-transferase and glutathione peroxidase were positively correlated with the expression levels of cytochrome P450 genes ( GST1-1 , GSTP , GSTK1 , HPGDS , UGT5 ), which are products of PFOS-induced oxidative stress and play an antioxidant role in the body. The results of this study provided valuable ecotoxicological data to better understand the biological fate and effects of PFOS in C. quadricarinatus .

分类号：

  • 相关文献
作者其他论文 更多>>

微信小程序