Juvenile hormone signaling regulates apoptosis mediated chlorantraniliprole sensitivity in Spodoptera frugiperda (Lepidoptera: Noctuidae)

文献类型： 外文期刊

第一作者： Luo, Jie

作者： Luo, Jie;Ouyang, Huili;Liu, Shiling;Wu, Haiyan;Li, Xuesheng;Xiong, Faqian;Yang, Taiyi;Li, Honghong

作者机构：

关键词： Fall armyworm; Juvenile hormone; Chlorantraniliprole; Apoptosis

期刊名称：PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY （ 影响因子：4.0； 五年影响因子：4.5 ）

ISSN： 0048-3575

年卷期： 2025 年 214 卷

页码：

收录情况： SCI

摘要： The fall armyworm (Spodoptera frugiperda, FAW) has developed varying degrees of resistance to chlorantraniliprole (CAP). Apoptosis serves as a critical defense mechanism against pesticide stress in insects. Here, we identified a juvenile hormone (JH)-mediated apoptotic pathway through RNA-seq, revealing nine JH-induced apoptosis-related genes (four positively correlated and five negatively correlated). Functional validation demonstrated that JH mitigates CAP-induced apoptosis by upregulating positively correlated genes (SfPIK3R1, SfIKBKB, SfCtsb-1, SfCtsb-2) and suppressing negatively correlated genes (SfCtsb-3, SfAif-1, SfAif-2, SfDredd, SfTuba). This dual regulation of apoptotic signaling suggests that JH indirectly modulates FAW sensitivity to CAP by balancing these nine genes expression. Additionally, JH may enhance resistance through concurrent upregulation of cytochrome P450 (CYP450) genes potentially involved in CAP metabolism. These findings provide novel insights into the molecular mechanisms underlying CAP resistance in FAW, highlighting the potential antagonistic mechanism of JH and CAP. This study underscores the importance of integrating hormonal and metabolic interactions in understanding and managing pesticide resistance in agricultural pests.

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