Characterization of a duck circovirus propagated in duck embryos: from genome to pathogenesis in SPF ducks

文献类型： 外文期刊

第一作者： Guo, Xiaozhen

作者： Guo, Xiaozhen;Liu, Liping;Zhu, Tong;Gao, Yuehua;Yin, Dan;Ma, Xiuli;Huang, Bing;Li, Yufeng;Qin, Zhuoming;Hu, Feng;Yu, Kexiang

作者机构：

关键词： Duck circovirus; Virus isolation; Genomics; Pathogenicity; Viral dynamics analysis

期刊名称：POULTRY SCIENCE （ 影响因子：4.2； 五年影响因子：4.5 ）

ISSN： 0032-5791

年卷期： 2025 年 104 卷 9 期

页码：

收录情况： SCI

摘要： Duck circovirus (DuCV) is a major pathogen in duck farming that causes immunosuppression and increases the susceptibility to secondary infections. This study focused on a Chinese DuCV strain, designated SDDC, which was isolated and characterized from Cherry Valley ducks in Shandong Province in 2022. The SDDC strain was successfully propagated in specific-pathogen-free (SPF) duck embryos and confirmed by transmission electron microscopy. Genomic analysis identified a complete genome of 1994 bp, with a critical amino acid mutation (I to T) at the 160th position in the Cap protein, potentially influencing viral tropism. Pathogenicity studies in 2-day-old SPF ducks revealed a multi-organ infection, with the spleen as the primary target, exhibiting the highest viral load and significant histopathological alterations. Analysis of multi-organ viral dynamics indicated a detectable viral presence across target organs as early as 3 dpi, followed by a progressive decline in viral load until day 7. A pronounced replication peak was observed on day 14, after which a gradual viral clearance occurred. This study provides critical insights into the genomics, pathogenicity, and tropism of DuCV, establishing a foundation for elucidating its infection mechanisms, and developing targeted control strategies to protect duck farming.

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