Nucleic acid-based reference materials: A "ruler" for precision molecular diagnostics

文献类型： 外文期刊

第一作者： Li, Kai

作者： Li, Kai;Guo, Yaning;Qi, Xin;Li, Fukai;Li, Xinran;Yang, Mengrui;Zhou, Jian;Li, Liang;Liu, Gang;Zhou, Haiwei

作者机构：

关键词： Analytical chemistry; Reference materials; Molecular detection; COVID-19

期刊名称：TRAC-TRENDS IN ANALYTICAL CHEMISTRY （ 影响因子：12.0； 五年影响因子：13.2 ）

ISSN： 0165-9936

年卷期： 2025 年 189 卷

页码：

收录情况： SCI

摘要： Analytical chemistry is experiencing a growing demand for reliable and traceable results, which have significant implications for public health and food safety. The COVID-19 pandemic further underscores the need for accurate and dependable molecular diagnostics. Nucleic acid-based reference materials (NARMs) play a crucial role in ensuring the quality of results. Notably, NARMs have gained increased attention following the outbreak of COVID-19. While previous reviews introduced NARMs but overlooked their applications in different fields. Moreover, the integration of multiple methods represents a new trend in the preparation of NARMs, but these have not appeared in previous reviews. Therefore, this review delineates NARMs classification, synthesizes characterization techniques, reviews their applications in virus diagnosis, animal diseases, pathogenic microorganisms, genetic diseases and genetically modified organism detection, and provides a perspective on NARMs' development and current challenges. In-depth study of NARMs will be significant for precise molecular diagnostics in biology, agriculture and public health.

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