Cloning and identification of porcine programmed death 1

文献类型： 外文期刊

第一作者： Zhou, Yan-Jun

作者： Zhou, Yan-Jun;Tong, Guang-Zhi;Peng, Jin-Mei;Tian, Zhi-Jun;An, Tong-Qing;Wang, Yao;Li, Deng-Yun;Chen, Jia-Zeng;Yang, Yong-Qian;Tong, Guang-Zhi;Peng, Jin-Mei;Tong, Guang-Zhi;Liu, Heng-Gui

作者机构：

关键词： immunoglobulin;amino acid;programmed death 1: PD-1;expression;identification

期刊名称：VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY （ 影响因子：2.046； 五年影响因子：2.217 ）

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收录情况： SCI

摘要： Programmed death 1 (PD-1) is a member of the immunoglobulin (Ig) superfamily, which is expressed on activated T cells, B cells and monocytes. Many researches have demonstrated that a high level of PD-1 expression is closely related to persistent infection and immune evasion in some human infections. In order to study the relationship between PD-1 expression and persistent infections caused by some porcine viruses, we first cloned the porcine PD-1 from porcine PBMCs based on the blast result in the EST database using the human PD-1 sequence. Sequence analysis showed that the cloned PD-1 molecule shares 63 and 54% amino acid sequence identity with human and murine PD-1, respectively. Its molecular structure is also similar to that of human and murine PD-1, containing an IgV-like domain in the extracellular region and two immune regulatory motifs in its cytoplasmic tail. The in vitro T cell proliferation assay showed that the cloned PD-1 could inhibit porcine T cell proliferation by 71% and secretion of INF-gamma and IL-2 by 64 and 53%, respectively. These data suggest that porcine PD-1 negatively regulates the porcine immune response in a similar manner to that of its counterpart in the human and mouse immune system

分类号： S85

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