Identification of a novel angiogenin inhibitor 1 and its association with hyaluronidase of Streptococcus suis serotype 2
文献类型: 外文期刊
第一作者: Chen, Huanchun
作者: Chen, Huanchun;Wo, Tao;Yuan, Fangyan;Chang, Haitao;Chen, Guangping;Tan, Chen;Chen, Huanchun;Bei, Weicheng;Zhang, Lin
作者机构:
关键词: Nervous System: Neural Coordination;Infection;Enzymology: Biochemistry and Molecular Biophysics
期刊名称:MICROBIAL PATHOGENESIS ( 影响因子:3.738; 五年影响因子:3.663 )
ISSN:
年卷期:
页码:
收录情况: SCI
摘要: To characterize the role of hyaluronidase (Hyl) of Streptococcus sins serotype 2 (S sins 2), the hylA gene that encodes Hyl was cloned, expressed and purified A murine brain cDNA library was used to screen for interacting proteins of Hyl Employing the yeast two-hybrid system, a novel murine ribonuclease, angiogenin inhibitor 1 (AI1), which shares 93% homology with porcine AI1, was shown to interact with Hyl in yeast Through co-immunoprecipitation assays, the interaction between AI1 and Hyl was further confirmed Transcription and translation products of the identified cDNA were detected in both normal cells and S suis 2-infected cells AI1 was found to localize mainly in the cytoplasm of 293T cells. These results suggested that the identified protein AI1 might be involved in the pathogenesis of meningitis through interaction with Hyl of S sins 2
分类号: R3
- 相关文献
作者其他论文 更多>>
-
Genome assembly and resequencing shed light on evolution, population selection, and sex identification in Vernicia montana
作者:Li, Wenying;Cao, Jie;Liu, Meilan;Long, Hongxu;Lin, Hai;Zhang, Lin;Li, Wenying;Dong, Xiang;Cao, Jie;Liu, Meilan;Long, Hongxu;Lin, Hai;Zhang, Lin;Li, Wenying;Zhang, Xingtan;Zhou, Xu;Cao, Heping
关键词:
-
Aquaculture in Zambia: The Current Status, Challenges, Opportunities and Adaptable Lessons Learnt from China
作者:Zhang, Lin;Hua, Fenglei;Xu, Pao;Zhang, Lin;Hua, Fenglei;Xu, Pao;Maulu, Sahya;Maulu, Sahya;Chama, Majory K. H.
关键词:Zambia; aquaculture; challenges; adaptable lessons
-
Physiological Mechanisms Underlying Tassel Symptom Formation in Maize Infected with Sporisorium reilianum
作者:Wang, Yuhe;Xu, Chuzhen;Gao, Yansong;Zhang, Xiaoming;Zhang, Lin;Di, Hong;Ma, Jinxin;Dong, Ling;Zeng, Xing;Zhang, Naifu;Xu, Jiawei;Li, Yujuan;Gao, Chao;Wang, Zhenhua;Zhou, Yu;Ma, Yanhua
关键词:maize; head smut; Sporisorium reilianum; tassel symptoms
-
Screening of Active Substances Regulating Alzheimer's Disease in Ginger and Visualization of the Effectiveness on 6-Gingerol Pathway Targets
作者:Pan, Yecan;Li, Zishu;Zhao, Xiaoyu;Du, Yang;Zhang, Lin;Lu, Yushun;Yang, Ling;Cao, Yilin;Qiu, Jing;Qian, Yongzhong;Pan, Yecan;Li, Zishu;Zhao, Xiaoyu;Du, Yang;Zhang, Lin;Lu, Yushun;Yang, Ling;Cao, Yilin;Qiu, Jing;Qian, Yongzhong
关键词:6-Gingerol; ginger; Alzheimer's disease (AD); network pharmacology; molecular dynamics (MD)
-
Two unprecedented neuroprotective 2-(2-phenylethyl)chromone derivatives from cultivated "Qi-Nan" agarwood of Aquilaria sinensis
作者:Zhang, Lin;Yang, Li;Li, Wei;Chen, Hui-Qin;Yuan, Jing-Zhe;Cai, Cai-Hong;Mei, Wen-Li;Dai, Hao-Fu;Zhang, Lin;Li, Zhen-Yu
关键词:Cultivated "Qi-Nan" agarwood; Aquilaria sinensis; 2-(2-phenylethyl)chromone; Neuroprotective activity
-
The impact of micropolymorphism in Anpl-UAA on structural stability and peptide presentation
作者:Tang, Ziche;Wang, Suqiu;Du, Liubao;Hu, Dongmei;Chen, Xiaoming;Zheng, Hanyin;Ding, Han;Chen, Shiwen;Zhang, Nianzhi;Zhang, Lin;Zhang, Lin
关键词:Micropolymorphism; Peptide presentation; RPLD-MS; Crystal structure
-
Seroprevalence survey of Hepatitis E Virus in Domestic Pigs in Guangdong, China
作者:Liu, Dingyu;Liu, Baoling;He, Zhenwen;Qiao, Changhong;Luo, Qin;Chen, Xiangyu;Wang, Xiaohu;Xiang, Hua;Chen, Jing;Zhang, Pian;Huang, Yuan;Wang, Gang;Cai, Rujian;Liu, Dingyu;Tan, Chen;He, Zhenwen
关键词:HEV; zoonoses; pigs; seroprevalence; ELISA