Effect of Black Tea Polysaccharides on Alleviating Type 2 Diabetes Mellitus by Regulating PI3K/Akt/GLUT2 Pathway

文献类型： 外文期刊

第一作者： Zhang, Zhenbiao

作者： Zhang, Zhenbiao;Deng, Xuming;Zhang, Lingzhi;Zhang, Zhenbiao;Chen, Ruohong;Li, Qiuhua;Sun, Lingli;Cao, Junxi;Lai, Zhaoxiang;Lai, Xingfei;Sun, Shili;Wang, Zaihua

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关键词： black tea; tea polysaccharides; chemical property; hypoglycemic effect; PI3K-Akt

期刊名称：FOODS （ 影响因子：4.7； 五年影响因子：5.1 ）

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年卷期： 2024 年 13 卷 12 期

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收录情况： SCI

摘要： The bioactivity of tea polysaccharides (TPs) has been widely reported, but studies to date have focused on green tea. Some human health investigations have implied that black tea may possess potential antidiabetic effects, but less is known about their potential role and related antidiabetic mechanism. The present study was, therefore, conducted to investigate the chemical properties and antidiabetic activity of TPs from black tea. Monosaccharide composition revealed that Alduronic acid (77.8 mol%) considerably predominated in the fraction. TP conformation analysis indicated that three components in TPs were all typical of high-branching structures. Oral administration of TPs could effectively alleviate fasting blood glucose in type 2 diabetes mellitus (T2D) mice, with the values 23.6 +/- 1.42, 19.6 +/- 2.25, and 16.4 +/- 2.07 mmol/L in the 200, 400, and 800 mg/kgBW groups, respectively. Among these TPs groups, the 800 mg/kgBW groups significantly decreased by 37.88% when compared with the T2D+water group (p < 0.05). Further studies demonstrated that TP treatment upregulated the expression of p-Akt/p-PI3K (p < 0.001). Additionally, TP treatment significantly promoted glucose transporter protein 2 (GLUT2) translocation in the liver (p < 0.001). These findings suggest that TPs from black tea protect against T2D by activating PI3K/Akt/GLUT2 signaling and might serve as a novel therapeutic candidate for T2D.

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