Salmonella YrbD protein mediates invasion into the host by interacting with β2 integrin

文献类型： 外文期刊

第一作者： Cao, Jun

作者： Cao, Jun;Wang, Jinliang;Dang, Guanghui;Ding, Shihao;Lu, Yao;Xu, Qiu;Liu, Siguo;Yu, Shenye

作者机构：

关键词： 132 integrin; adhesion; internalization; Salmonella; protein YrbD

期刊名称：JOURNAL OF INTEGRATIVE AGRICULTURE （ 影响因子：4.4； 五年影响因子：4.8 ）

ISSN： 2095-3119

年卷期： 2025 年 24 卷 3 期

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收录情况： SCI

摘要： Salmonella enterica serovar Typhimurium, the causative agent of gastroenteritis, is one of the most successful intracellular pathogens. Although certain host factors for Salmonella infection have been unveiled, the factors mediating Salmonella entry, particularly the invasion process, remain obscure. Here, we have unearthed 132 integrin, a crucial member of the integrin family, as an important host factor facilitating Salmonella invasion. It is demonstrated that overexpression of 132 integrin promotes Salmonella invasion, while the knockdown of 132 integrin significantly diminishes the extent of invasion. Moreover, Salmonella exhibits specific binding affinity towards 132 integrin, and the block of 132 integrin on cell surface substantially reduces the infection of cells in vitro. The ectodomain soluble protein of 132 integrin neutralized Salmonella infection both in cells (in vitro) and in mice (in vivo). Additionally, Salmonella protein YrbD directly interacts with 132 integrin to facilitate its invasion. To our knowledge, this study showed for the first time that the protein YrbD mediates Salmonella adhesion and internalization into host cells by interacting with 132 integrin. These findings not only broaden our understanding of the mechanisms underlying Salmonella entry, but also identify a prospective target for therapeutic control.

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