Different Durations of Simulated Weightlessness Induced Depressive like Behaviors in Rats

文献类型： 外文期刊

第一作者： Zhang Mi-Jia

作者： Zhang Mi-Jia;Wang Meng-Di;Ayaz, Ahmed;Dong Li;Liu Xin-Min;Wang Qiong;Zhang Mi-Jia;Wang Qiong;Wang Meng-Di;Yao Qin-Wei;Li Ying-Hui;Qu Li-Na;Chen Shan-Guang;Liu Xin-Min;Ayaz, Ahmed

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关键词： simulated weightlessness; depressive like behaviors; open field test; forced swim test; superoxide dismutase; catalase

期刊名称：PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS （ 影响因子：0.3； 五年影响因子：0.3 ）

ISSN： 1000-3282

年卷期： 2023 年 50 卷 2 期

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收录情况： SCI

摘要： Objective This study was designed to observe different durations of simulated weightlessness induced depressive-like behaviors and the change of superoxide dismutase (SOD) and catalase (CAD in hippocampi of rats, so as to explore its effects and possible mechanism. Methods Weightlessness was simulated by hindlimb suspension by tails (HLS) in rats. The rats were divided into the control and the HLS groups for each respective week (s), i. e., 1, 2, 3, and 4. The depressive-like behaviors in rats were investigated by using the open field test (OFT), novel object recognition test (NORT), forced swim test (FST), followed by hippocampal protein level estimation of SOD and CAT by ELISA. Results The OFT results showed increased stagnation time among HLS rats in each respective group compared to their corresponding control groups (P<0.05, P<0.01). In the NORT, the latency of exploration increased, while the number and the time of exploration decreased in the HLS groups in each week, compared to their corresponding control rats (P<0.05, P<0.01). Similarly, FST displayed enhanced immobility with the reduced climbing rate in HLS rats in each respective week, compared to the normal rats (P<0.05, P<0.01). Simulated weightlessness significantly reduced the SOD and CAT levels in the hippocampi in HLS rats compared to the normal rats (P<0.05, P<0.01). Conclusion Results suggest that short or long weightlessness could induce depressive-like behaviors in rats.

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