Photosensitizer-based small molecule theranostic agents for tumor-targeted monitoring and phototherapy

文献类型： 外文期刊

第一作者： Gao, Jiake

作者： Gao, Jiake;Jiang, Hongfei;Zhang, Renshuai;Liu, Ning;Chen, Pengwei

作者机构：

关键词： Theranostic; Photosensitizer; Phototherapy; Tumor -targeted imaging; Drug design

期刊名称：BIOORGANIC CHEMISTRY （ 影响因子：5.1； 五年影响因子：5.3 ）

ISSN： 0045-2068

年卷期： 2023 年 136 卷

页码：

收录情况： SCI

摘要： Small molecule theranostic agents for tumor treatment exhibited triadic properties in tumor targeting, imaging, and therapy, which have attracted increasing attention as a potential complement for, or improved to, classical small molecule antitumor drugs. Photosensitizer have dual functions of imaging and phototherapy, and have been widely used in the construction of small molecule theranostic agents over the last decade. In this review, we summarized representative agents that have been studied in the field of small molecule theranostic agents based on photosensitizer in the last decade, and highlighted their characteristics and application in tumor-targeted monitoring and phototherapy. The challenges and future perspectives of photosensitizers in building small molecule theranostic agents for diagnosis and therapy of tumors were also discussed.

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