The Hippo-Yki pathway downstream transcription factor Scalloped negatively regulates immune defense against Vibrio parahaemolyticus infection in shrimp

文献类型： 外文期刊

第一作者： Yang, Linwei

作者： Yang, Linwei;Han, Deyu;Wang, Zi-ang;Chen, Nuo;Zuo, Hongliang;Xu, Menghuang;Weng, Shaoping;He, Jianguo;Xu, Xiaopeng;Yang, Linwei;Han, Deyu;Wang, Zi-ang;Chen, Nuo;Zuo, Hongliang;Xu, Menghuang;Weng, Shaoping;He, Jianguo;Xu, Xiaopeng;Yang, Linwei;Han, Deyu;Wang, Zi-ang;Chen, Nuo;Zuo, Hongliang;He, Jianguo;Xu, Xiaopeng;Guo, Zhixun;Xu, Xiaopeng

作者机构：

期刊名称：FISH & SHELLFISH IMMUNOLOGY （ 影响因子：4.7； 五年影响因子：4.7 ）

ISSN： 1050-4648

年卷期： 2023 年 139 卷

页码：

收录情况： SCI

摘要： The Hippo-Yki signaling pathway plays a crucial role in numerous biological processes. Previous studies have demonstrated the significance of signal transduction components of the Hippo pathway in the immune response of shrimp. In this study, the downstream transcription factor of Hippo signaling, Scalloped, was analyzed upregulated in hemocytes. Scalloped was found to localize in the nucleus and interact with the Hippo pathway downstream transcriptional co-activator Yki. With the the NF-& kappa;B family member Dorsal in shrimp. By inhibiting the Dorsal pathway, Scalloped reduced the expression of immune functional proteins and negatively regulated the immune response against bacterial infection in shrimp. RNAi-mediated silencing of Scalloped significantly enhanced the survival rate of V. parahaemolyticus-infected shrimp and reduced the bacterial load in tissues. These findings demonstrate the potential of Scalloped as a therapeutic target for vibriosis in crustaceans and contribute to our understanding of the shrimp's antibacterial defense and the functional roles of Hippo signaling in animal immunity.

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