Research Note: Pathogenetic characteristics of avian encephalomyelitis virus in Guangdong and Jiangxi Provinces, China

文献类型： 外文期刊

第一作者： Zhang, Fanfan

作者： Zhang, Fanfan;Wei, Qipeng;Xiong, Ligen;Tan, Jia;Wu, Chengcheng;Li, Na;Kang, Zhaofeng;Luo, Yangyang;Xie, Quan

作者机构：

关键词： avian encephalomyelitis virus; surveillance; epidemiological characteristic; phylogenetic analysis

期刊名称：POULTRY SCIENCE （ 影响因子：4.4； 五年影响因子：4.4 ）

ISSN： 0032-5791

年卷期： 2024 年 103 卷 2 期

页码：

收录情况： SCI

摘要： In recent years, the infection rate of avian encephalomyelitis virus (AEV) infection in chick-ens has risen significantly, seriously endangering the development of the chicken industry. In order to study the current epidemiological status of AEV in China as well as the genetic and evolutionary patterns of the virus, we conducted a survey and genomic analysis of chicken AEV. The results showed that 46.26% (136/ 294) of the tissue samples tested (n = 294) were positive for AEV, with the highest positivity rate of 62.24% (61/ 98) among tissue samples from chickens aged 13 to 18 wk. The complete genomes of 2 representative AEV strains were determined, and the VP1 evolutionary tree results revealed that the 2 representative strains belonged to a novel AEV strain. Multiple alignment analysis showed that the ORF1 genes of the 2 represen-tative strains differed by 82.3 to 99.9% at the amino acid level compared with the reference AEV strain, and the mutations at the key amino acid loci of VP2 and VP3 were the same as those in the chick embryo-adapted strain. The analysis makes up for the molecular epidemi-ological data and genetic variation of the 2 representa-tive strains. The analysis makes up for the molecular epidemiological data and genetic variation of AEV and provides a basis for further understanding the spread of AEV in China.

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