Integrated analysis of whole genome and transcriptome sequencing uncovers genetic differences between Zi goose and Xianghai flying goose

文献类型： 外文期刊

第一作者： Ni, Hongyu

作者： Ni, Hongyu;Zhang, Yonghong;Yang, Yuwei;Yin, Yijing;Ren, Jing;Xiao, Qingxing;Zhao, Puze;Hong, Xiaoqing;Zhang, Ziyi;Sun, Hao;Sun, Xueqi;Li, Yumei;Cui, Benhai;Sun, Xueqi

作者机构：

关键词： F-ST; RNA-seq; Xianghai flying goose; XP-EHH; Zi goose

期刊名称：ANIMAL GENETICS （ 影响因子：2.4； 五年影响因子：2.8 ）

ISSN： 0268-9146

年卷期： 2023 年

页码：

收录情况： SCI

摘要： Zi goose is a famous indigenous breed originating from northeast China with high annual egg production. Xianghai flying goose is a composite breed and is bred by crosses of the wild swan goose and the Zi goose. Our previous study revealed significant differences in muscle fiber characteristics between the two populations. Here, we aimed to reveal the underlying genetic basis of the above phenotype differences through whole-genome and transcriptome analysis. A total of 20 blood samples (10 Zi geese and 10 Xianghai flying geese) were used for whole genome sequencing, and eight breast muscle tissue samples (four Zi geese and four Xianghai flying geese) were used for RNA sequencing. Using the F-ST and XP-EHH analysis, some highly differentiated genome regions annotated with egg production (RORB, WNT4, BMPR1B) and breast muscle development (WNT7B) between the two populations were detected. RNA-sequencing analysis revealed differentially expressed genes related to muscle development (IGF1, PAX7). Moreover, several genes were detected by both genome and transcriptome analysis, and some of them were reported to be associated with muscle growth (SLIT2, PREX1) and intramuscular fat (COL6A1). These findings will help researchers better understand the genetic basis related to egg production and muscle development in geese.

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